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K-Ras(G12C) inhibitor 6

Name: K-Ras(G12C) inhibitor 6
Brand: TargetMol
SKU: T3725
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T3725 Copy Product Info

Purity: 97.09%

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K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant, achieving 100% protein modification at 10 μM after 24 hours in vitro.

K-Ras(G12C) inhibitor 6

Copy Product Info

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Catalog No. T3725

K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant, achieving 100% protein modification at 10 μM after 24 hours in vitro.

Cas No. 2060530-16-5

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Pack Size	Price	USA Stock	Global Stock
1 mg	$34	In Stock	In Stock
5 mg	$81	In Stock	In Stock
10 mg	$146	In Stock	In Stock
25 mg	$302	In Stock	In Stock
50 mg	$421	In Stock	In Stock
100 mg	$589	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$81	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.09%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

K-Ras(G12C) inhibitor 6 AI Summary

K-Ras(G12C) inhibitor 6 shows antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in both Caco-2 and VERO-6 cells at a concentration of 10 µM, with inhibition percentages recorded at -8.63% and -0.12% respectively after 48 hours of exposure. Additionally, it inhibits the SARS-CoV-2 3CL-Pro protease by 3.635% at a concentration of 20 µM. This compound also demonstrates inhibitory activity against human HDAC6, with 20.55% inhibition in an enzymatic assay using a commercial peptide substrate, and 7.84% inhibition in an assay using a custom peptide substrate. These combined activities highlight K-Ras(G12C) inhibitor 6's potential as a multifunctional agent against SARS-CoV-2..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant, achieving 100% protein modification at 10 μM after 24 hours in vitro.

Chemical Properties

Molecular Weight	405.34
Formula	C₁₇H₂₂Cl₂N₂O₃S
Cas No.	2060530-16-5
Smiles	C(COC1=C(Cl)C=C(Cl)C=C1)(=O)N2CCC(NC(CCCS)=O)CC2
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 73 mg/mL (180.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4671 mL	12.3353 mL	24.6706 mL	123.3532 mL
5 mM	0.4934 mL	2.4671 mL	4.9341 mL	24.6706 mL
10 mM	0.2467 mL	1.2335 mL	2.4671 mL	12.3353 mL
20 mM	0.1234 mL	0.6168 mL	1.2335 mL	6.1677 mL
50 mM	0.0493 mL	0.2467 mL	0.4934 mL	2.4671 mL
100 mM	0.0247 mL	0.1234 mL	0.2467 mL	1.2335 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc