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(S)-10-Hydroxycamptothecin
🥰Excellent
Catalog No. T2764Cas No. 19685-09-7
Alias 10-Hydroxycamptothecin, 10-HCPT
(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor used as a clinical therapeutic agent against hepatoma.
(S)-10-Hydroxycamptothecin
🥰Excellent
Purity: 99.81%
Catalog No. T2764Alias 10-Hydroxycamptothecin, 10-HCPTCas No. 19685-09-7
(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor used as a clinical therapeutic agent against hepatoma.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 200 mg | $51 | In Stock | In Stock | |
| 500 mg | $108 | In Stock | In Stock | |
| 1 g | $189 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.81%
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Product Introduction
Bioactivity
Chemical Properties
| Description | (S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor used as a clinical therapeutic agent against hepatoma. |
| In vitro | In the CAM model, 10-Hydroxycamptothecin (25 nM) inhibits angiogenesis in a concentration-dependent manner. In mice carrying Colo 205 xenografts, oral administration of 10-Hydroxycamptothecin (2.5-7.5 mg/kg) every two days significantly suppresses tumor cell growth. |
| In vivo | (S)-10-Hydroxycamptothecin inhibits cell growth in BT-20 cells (IC50=34.3 nM) and MDA-231 cells (IC50=7.27 nM), demonstrating its efficacy. It also induces the formation of cleavable complexes mediated by human topoisomerase I in pBR322 plasmid DNA (EC50=0.35 μM). Additionally, in human microvascular endothelial cells (HMEC), (S)-10-Hydroxycamptothecin dose-dependently inhibits cell growth (IC50=0.31 μM), significantly hampers HMEC migration (IC50=0.63 μM), and impedes angiogenesis (IC50=0.96 μM). |
| Cell Research | Cells are exposed to various concentrations of 10-Hydroxycamptothecin for 72 hours. Cell growth is monitored by the standard MTT assay.(Only for Reference) |
| Synonyms | 10-Hydroxycamptothecin, 10-HCPT |
| Molecular Weight | 364.35 |
| Formula | C20H16N2O5 |
| Cas No. | 19685-09-7 |
| Smiles | O=C1N2C(C=3C(C2)=CC=4C(N3)=CC=C(O)C4)=CC5=C1COC(=O)[C@@]5(CC)O |
| Relative Density. | 1.60 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 26 mg/mL (71.36 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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