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Ebopiprant

Name: Ebopiprant
Brand: TargetMol
SKU: T12285
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12285Cas No. 2005486-31-5

Alias OBE-022, OBE022

Ebopiprant (OBE022) is an orally available, selective and potent prostaglandin F2α (PGF2α) receptor antagonist that interferes with the binding of PGF0126α to the FPR and can be used in the study of obesity.

Ebopiprant

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Purity: 98.73%

Catalog No. T12285Alias OBE-022, OBE022Cas No. 2005486-31-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$199	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.73%

Appearance:Solid

Color:White

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COA HNMR MS LCMS

Product Introduction

Bioactivity

Description	Ebopiprant (OBE022) is an orally available, selective and potent prostaglandin F2α (PGF2α) receptor antagonist that interferes with the binding of PGF0126α to the FPR and can be used in the study of obesity.
Targets&IC50	FPR:26 nM (Ki, Rat), FPR:1 nM (Ki, Human)
In vitro	Ebopiprant (OBE022) and OBE002 undergo FP binding affinity assays via competitive binding with 3H-PGF2α, utilizing HEK293 cells stably transfected with the FP receptor. The binding affinities (Ki) of Ebopiprant (OBE022) for human and rat FP receptors are 1 nM and 26 nM, respectively, while for OBE002, they are 6 nM for human FP and 313 nM for rat FP. The binding of both compounds is reversible and competitive, with increasing concentrations leading to decreased slopes of the binding curves, indicating an increase in the equilibrium dissociation constant (KD) without reducing receptor density[1].
In vivo	In the time-course study of the cumulative percentage of delivered mice after RU486-induced preterm parturition at GD17, oral treatment with Ebopiprant (OBE022)or nifedipine, as well as vehicle treatment, was assessed. Both Ebopiprant (OBE022) and nifedipine treatments resulted in a delay in preterm birth caused by RU486 administration, evidenced by a rightward shift in the percentage of delivery curve. Notably, both compounds showed a trend towards an increased time to the first pup delivery. This prolongation of gestation led to the delivery of viable pups.Furthermore, the combination of Ebopiprant (OBE022) and nifedipine exhibited a synergistic effect on delaying RU486-induced preterm birth, as indicated by a more pronounced rightward shift in the percentage of delivery curve compared to Ebopiprant (OBE022) or nifedipine alone. Additionally, a larger increase in the time of the first pup delivery was observed with the combination treatment[1].
Synonyms	OBE-022, OBE022

Chemical Properties

Molecular Weight	599.74
Formula	C₃₀H₃₄FN₃O₅S₂
Cas No.	2005486-31-5
Smiles	CC(C)[C@H](N)C(=O)OCC[C@H](NC(=O)[C@@H]1SCCN1S(=O)(=O)c1ccc(cc1)-c1ccccc1)c1ccc(F)cc1
Relative Density.	1.300 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (166.74 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6674 mL	8.3369 mL	16.6739 mL	83.3695 mL
5 mM	0.3335 mL	1.6674 mL	3.3348 mL	16.6739 mL
10 mM	0.1667 mL	0.8337 mL	1.6674 mL	8.3369 mL
20 mM	0.0834 mL	0.4168 mL	0.8337 mL	4.1685 mL
50 mM	0.0333 mL	0.1667 mL	0.3335 mL	1.6674 mL
100 mM	0.0167 mL	0.0834 mL	0.1667 mL	0.8337 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc