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TDI-10229

Catalog No. T64355   CAS 2810887-45-5

TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50= 195 nM). TDI-10229 exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound.

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TDI-10229 Chemical Structure
TDI-10229, CAS 2810887-45-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 97.00
5 mg In stock $ 247.00
10 mg In stock $ 397.00
25 mg In stock $ 663.00
50 mg In stock $ 945.00
100 mg In stock $ 1,280.00
500 mg In stock $ 2,570.00
1 mL * 10 mM (in DMSO) In stock $ 259.00
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Purity: 97.77%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50= 195 nM). TDI-10229 exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound.
In vitro TDI-10229 inhibits human 4-4 cells with an IC50 of 92 nM for[2].
In vivo TDI-10229 (20 mg/kg; p.o.) treatment in mouse shows the AUC, Cmax, and MRT were 94 μg h/mL, 15.5 μM, and 3.95 hours, respectively[2].
Molecular Weight 313.78
Formula C16H16ClN5
CAS No. 2810887-45-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 112.5 mg/mL (358.5 mM), sonification is recommended.

TargetMolReferences and Literature

1. Balbach M, et al. Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization [published online ahead of print, 2021 Aug 31]. Mol Hum Reprod. 2021;gaab054. 2. Fushimi M, et al. Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). ACS Med Chem Lett. 2021;12(8):1283-1287. Published 2021 Jul 14.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Bioactive Compounds Library Max Inhibitor Library

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Keywords

TDI-10229 2810887-45-5 GPCR/G Protein cAMP TDI10229 CompoundTDI10229 TDI 10229 inhibitor inhibit

 

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