Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50= 195 nM). TDI-10229 exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 397.00 | |
25 mg | In stock | $ 663.00 | |
50 mg | In stock | $ 945.00 | |
100 mg | In stock | $ 1,280.00 | |
500 mg | In stock | $ 2,570.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 259.00 |
Description | TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50= 195 nM). TDI-10229 exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound. |
In vitro | TDI-10229 inhibits human 4-4 cells with an IC50 of 92 nM for[2]. |
In vivo | TDI-10229 (20 mg/kg; p.o.) treatment in mouse shows the AUC, Cmax, and MRT were 94 μg h/mL, 15.5 μM, and 3.95 hours, respectively[2]. |
Molecular Weight | 313.78 |
Formula | C16H16ClN5 |
CAS No. | 2810887-45-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 112.5 mg/mL (358.5 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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TDI-10229 2810887-45-5 GPCR/G Protein cAMP TDI10229 CompoundTDI10229 TDI 10229 inhibitor inhibit