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TDI-10229

🥰Excellent
Catalog No. T64355Cas No. 2810887-45-5

TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10), displaying nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 = 195 nM). TDI-10229 exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound.

TDI-10229

TDI-10229

🥰Excellent
Purity: 99.89%
Catalog No. T64355Cas No. 2810887-45-5
TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10), displaying nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 = 195 nM). TDI-10229 exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$35In StockIn Stock
5 mg$168In StockIn Stock
10 mg$248In StockIn Stock
25 mg$455In StockIn Stock
50 mg$683In StockIn Stock
100 mg$987-In Stock
200 mg$1,330-In Stock
1 mL x 10 mM (in DMSO)$186In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.89%
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Product Introduction

Bioactivity
Description
TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10), displaying nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 = 195 nM). TDI-10229 exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound.
In vitro
TDI-10229 inhibits human 4-4 cells with an IC50 of 92 nM for[2].
In vivo
TDI-10229 (20 mg/kg; p.o.) treatment in mouse shows the AUC, Cmax, and MRT were 94 μg h/mL, 15.5 μM, and 3.95 hours, respectively[2].
Chemical Properties
Molecular Weight313.78
FormulaC16H16ClN5
Cas No.2810887-45-5
SmilesCc1c(Cc2ccccc2)c(nn1C)-c1cc(Cl)nc(N)n1
Relative Density.1.34 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 112.5 mg/mL (358.5 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.75 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1869 mL15.9347 mL31.8695 mL159.3473 mL
5 mM0.6374 mL3.1869 mL6.3739 mL31.8695 mL
10 mM0.3187 mL1.5935 mL3.1869 mL15.9347 mL
20 mM0.1593 mL0.7967 mL1.5935 mL7.9674 mL
50 mM0.0637 mL0.3187 mL0.6374 mL3.1869 mL
100 mM0.0319 mL0.1593 mL0.3187 mL1.5935 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TDI-10229TDI10229TDI 10229sACCompoundTDI10229
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