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Procainamide hydrochloride

Name: Procainamide hydrochloride
Brand: TargetMol
SKU: T0018
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0018Cas No. 614-39-1

Alias Pronestyl, Procapan, Procanbid, Procainamide HCl

Procainamide Hydrochloride (Procapan) is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential.

Procainamide hydrochloride

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Purity: 99.97%

Catalog No. T0018Alias Pronestyl, Procapan, Procanbid, Procainamide HClCas No. 614-39-1

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$31	In Stock	In Stock
50 mg	$41	In Stock	In Stock
100 mg	$59	In Stock	In Stock
500 mg	$138	In Stock	In Stock
1 g	$198	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Procainamide hydrochloride AI Summary

Procainamide hydrochloride exhibits diverse bioactivities across multiple biological systems. In in vitro electrophysiological studies on canine cardiac tissues, it impacts action potential duration (APD95), with a decrease of up to -8.0% at 10 µM, and shows minimal changes in Vmax and conduction time (CT) at 0.1-100 µM concentrations. It increases the functional refractory period (FRP) by 2.0% to 27.0% at 10 µM. Additionally, it demonstrates antiarrhythmic activity in ouabain intoxicated dog models at 29.0 mg/kg and reduces normal beats in dogs following i.v. infusion. Moreover, in molecular assays, it shows potent modulation of Lamin A splicing (4.0 nM) and inhibition of various targets, including Bloom's syndrome helicase (50.1 nM) and Marburg Virus (177.8 nM). In antiviral studies, it affects SARS-CoV-2 induced cytotoxicity and the 3CL-Pro protease, though with varying degrees of inhibition. Its antifungal and antibacterial activities extend across multiple pathogens, including Candida albicans and Pseudomonas aeruginosa. Procainamide hydrochloride's diverse profile suggests potential therapeutic applications, though variability in specific activity levels indicates the need for targeted research..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

Pronestyl, Procapan, Procanbid, Procainamide HCl

Chemical Properties

Molecular Weight	271.79
Formula	C₁₃H₂₁N₃O·HCl
Cas No.	614-39-1
Smiles	Cl.CCN(CC)CCNC(=O)C1=CC=C(N)C=C1
Relative Density.	1.2027 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (165.57 mM), Sonication is recommended.

H2O: 183.97 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (9.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.6793 mL	18.3966 mL	36.7931 mL	183.9656 mL
5 mM	0.7359 mL	3.6793 mL	7.3586 mL	36.7931 mL
10 mM	0.3679 mL	1.8397 mL	3.6793 mL	18.3966 mL
20 mM	0.1840 mL	0.9198 mL	1.8397 mL	9.1983 mL
50 mM	0.0736 mL	0.3679 mL	0.7359 mL	3.6793 mL
100 mM	0.0368 mL	0.1840 mL	0.3679 mL	1.8397 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc