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SKF 38393 hydrochloride

Name: SKF 38393 hydrochloride
Brand: TargetMol
SKU: T6988
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6988Cas No. 62717-42-4

Alias SKF-38393A, SKF38393 HCl, (±)-SKF-38393 hydrochloride

SKF 38393 hydrochloride (SKF38393 HCl) is a selective dopamine D1/D5 receptor agonist.

SKF 38393 hydrochloride

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Purity: 99.51%

Catalog No. T6988Alias SKF-38393A, SKF38393 HCl, (±)-SKF-38393 hydrochlorideCas No. 62717-42-4

SKF 38393 hydrochloride (SKF38393 HCl) is a selective dopamine D1/D5 receptor agonist.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$33	In Stock	In Stock
25 mg	$50	In Stock	In Stock
50 mg	$71	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$78	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.51%

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SKF 38393 hydrochloride (SKF38393 HCl) is a selective dopamine D1/D5 receptor agonist.
Targets&IC50	D1:110 nM
In vitro	SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. [1] In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. [2] In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations. [4]
In vivo	SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. [3] In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning. [5]
Synonyms	SKF-38393A, SKF38393 HCl, (±)-SKF-38393 hydrochloride

Chemical Properties

Molecular Weight	291.77
Formula	C₁₆H₁₇NO₂·HCl
Cas No.	62717-42-4
Smiles	Cl.Oc1cc2CCNCC(c3ccccc3)c2cc1O
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 6 mg/mL (20.56 mM), Heating is recommended.

H2O: 6.25 mg/mL (21.42 mM), Sonication is recommended.

DMSO: 62.5 mg/mL (214.21 mM), Sonication is recommended.

In Vivo Formulation

4% DMSO+96% Saline: 6 mg/mL (20.56 mM)

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4274 mL	17.1368 mL	34.2736 mL	171.3679 mL
5 mM	0.6855 mL	3.4274 mL	6.8547 mL	34.2736 mL
10 mM	0.3427 mL	1.7137 mL	3.4274 mL	17.1368 mL
20 mM	0.1714 mL	0.8568 mL	1.7137 mL	8.5684 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc