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Cdk1/2 Inhibitor III

🥰Excellent
Catalog No. T14914Cas No. 443798-55-8

Cdk1/2 Inhibitor III is a selective inhibitor of Cdk1/2 with an IC50 value of 2.1 μM against CDK1/cyclin B.

Cdk1/2 Inhibitor III

Cdk1/2 Inhibitor III

🥰Excellent
Purity: 99.07%
Catalog No. T14914Cas No. 443798-55-8
Cdk1/2 Inhibitor III is a selective inhibitor of Cdk1/2 with an IC50 value of 2.1 μM against CDK1/cyclin B.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$123In StockIn Stock
5 mg$496In StockIn Stock
10 mg$795In StockIn Stock
25 mg$1,180In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.07%
ee:100%
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COA FNMR LCMS HNMR CSFC

Product Introduction

Bioactivity
Description
Cdk1/2 Inhibitor III is a selective inhibitor of Cdk1/2 with an IC50 value of 2.1 μM against CDK1/cyclin B.
Targets&IC50
CDK1-CyclinB:2.1 μM, CDK2-CyclinA:0.5 nM, CDK1-CyclinB:0.6 nM
In vitro
Cdk1/2 Inhibitor III exhibits weak CDK1 inhibition and possesses cellular antiproliferative properties.[1]
Chemical Properties
Molecular Weight425.44
FormulaC15H13F2N7O2S2
Cas No.443798-55-8
SmilesC(NC1=C(F)C=CC=C1F)(=S)N2C(NC3=CC=C(S(N)(=O)=O)C=C3)=NC(N)=N2
Relative Density.1.72 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (105.77 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3505 mL11.7525 mL23.5051 mL117.5254 mL
5 mM0.4701 mL2.3505 mL4.7010 mL23.5051 mL
10 mM0.2351 mL1.1753 mL2.3505 mL11.7525 mL
20 mM0.1175 mL0.5876 mL1.1753 mL5.8763 mL
50 mM0.0470 mL0.2351 mL0.4701 mL2.3505 mL
100 mM0.0235 mL0.1175 mL0.2351 mL1.1753 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

CDK2CDK1/CyclinBCdk1/cyclin BCdk-1/2 Inhibitor IIICdk1/2 Inhibitor III
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