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Mofezolac

Name: Mofezolac
Brand: TargetMol
SKU: T5460
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5460Cas No. 78967-07-4

Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000

Mofezolac

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Purity: 99.29%

Catalog No. T5460Cas No. 78967-07-4

Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$33	In Stock	In Stock
10 mg	$58	In Stock	In Stock
25 mg	$119	In Stock	In Stock
50 mg	$187	In Stock	In Stock
100 mg	$283	In Stock	In Stock
200 mg	$416	In Stock	-
1 mL x 10 mM (in DMSO)	$37	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.29%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Mofezolac AI Summary

Mofezolac exhibits potent bioactivity as an inhibitor of COX1 and COX2 enzymes, with an IC50 of 1.4 nM for COX1 and 440.0 nM for COX2, indicating a higher affinity for COX1. It demonstrates broad bioactivity across various biological processes including inhibition of T. brucei phosphofructokinase, delaying malarial parasite death, affecting Schwann cells, DNA re-replication in colon adenocarcinoma cells, and inhibiting Lassa Virus binding or entry. It also shows properties such as high permeability in human Caco2 cells and selective inhibition of COX1 over COX2 with minimal hemolysis and notable antiplatelet and anticoagulant activity. However, it exhibits moderate liver toxicity with elevated ALT, AST, and alkaline phosphatase, though acute or chronic severe liver conditions were not noted in clinical trials. Mofezolac also depicts low antiviral activity against SARS-CoV-2 in specific cell assays but exhibits some inhibitory action on the virus in HRCE cells. The compound’s varied bioactivities suggest potential therapeutic applications while highlighting the need to consider its liver toxicity profile..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000
Targets&IC50	COX-1:1.44 nM (IC50), COX-2:447 nM (IC50)

Chemical Properties

Molecular Weight	339.34
Formula	C₁₉H₁₇NO₅
Cas No.	78967-07-4
Smiles	COc1ccc(cc1)-c1noc(CC(O)=O)c1-c1ccc(OC)cc1
Relative Density.	1.25g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: Insoluble

DMSO: 55 mg/mL (162.08 mM), Sonication is recommended.

H2O: Insoluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9469 mL	14.7345 mL	29.4690 mL	147.3448 mL
5 mM	0.5894 mL	2.9469 mL	5.8938 mL	29.4690 mL
10 mM	0.2947 mL	1.4734 mL	2.9469 mL	14.7345 mL
20 mM	0.1473 mL	0.7367 mL	1.4734 mL	7.3672 mL
50 mM	0.0589 mL	0.2947 mL	0.5894 mL	2.9469 mL
100 mM	0.0295 mL	0.1473 mL	0.2947 mL	1.4734 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc