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Anti-CDH1/E-cadherin/CD324 Antibody is a monoclonal antibody targeting E-cadherin (encoded by the CDH1 gene). E-cadherin is a calcium-dependent cell adhesion molecule essential for maintaining the structural integrity and polarity of epithelial cells. By specifically binding to the extracellular domain of E-cadherin, this antibody is frequently utilized to study cell-cell adhesion mechanisms, the epithelial-mesenchymal transition (EMT) process, and tumor invasion and metastasis. In various cancers, the downregulation or loss of E-cadherin is considered a key hallmark of malignant progression and metastasis.

| Description | Anti-CDH1/E-cadherin/CD324 Antibody is a monoclonal antibody targeting E-cadherin (encoded by the CDH1 gene). E-cadherin is a calcium-dependent cell adhesion molecule essential for maintaining the structural integrity and polarity of epithelial cells. By specifically binding to the extracellular domain of E-cadherin, this antibody is frequently utilized to study cell-cell adhesion mechanisms, the epithelial-mesenchymal transition (EMT) process, and tumor invasion and metastasis. In various cancers, the downregulation or loss of E-cadherin is considered a key hallmark of malignant progression and metastasis. |
| In vitro | In immunofluorescence studies, Anti-CDH1/E-cadherin/CD324 Antibody showed strong and specific reactivity with epithelial tissues, such as the lining of the intestine and kidney tubules, localizing primarily to the cell-cell interface of the plasma membrane [1]. |
| In vivo | In mouse embryo assays, the addition of Anti-CDH1/E-cadherin/CD324 Antibody (anti-uvomorulin) to 8-cell stage embryos caused complete decompaction within 2-4 hours, demonstrating that the antibody effectively disrupts the calcium-dependent cell-cell adhesion required for blastocyst formation [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | CDH1/E-cadherin/CD324 |
| Isotype | IgG1 |
| Storage | store at low temperature | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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