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Anti-CDH1/E-cadherin/CD324 Antibody

🥰Excellent
Catalog No. T9901A-1434

Anti-CDH1/E-cadherin/CD324 Antibody is a monoclonal antibody targeting E-cadherin (encoded by the CDH1 gene). E-cadherin is a calcium-dependent cell adhesion molecule essential for maintaining the structural integrity and polarity of epithelial cells. By specifically binding to the extracellular domain of E-cadherin, this antibody is frequently utilized to study cell-cell adhesion mechanisms, the epithelial-mesenchymal transition (EMT) process, and tumor invasion and metastasis. In various cancers, the downregulation or loss of E-cadherin is considered a key hallmark of malignant progression and metastasis.

Anti-CDH1/E-cadherin/CD324 Antibody

Anti-CDH1/E-cadherin/CD324 Antibody

🥰Excellent
Catalog No. T9901A-1434
Anti-CDH1/E-cadherin/CD324 Antibody is a monoclonal antibody targeting E-cadherin (encoded by the CDH1 gene). E-cadherin is a calcium-dependent cell adhesion molecule essential for maintaining the structural integrity and polarity of epithelial cells. By specifically binding to the extracellular domain of E-cadherin, this antibody is frequently utilized to study cell-cell adhesion mechanisms, the epithelial-mesenchymal transition (EMT) process, and tumor invasion and metastasis. In various cancers, the downregulation or loss of E-cadherin is considered a key hallmark of malignant progression and metastasis.
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Product Introduction

Bioactivity
Description
Anti-CDH1/E-cadherin/CD324 Antibody is a monoclonal antibody targeting E-cadherin (encoded by the CDH1 gene). E-cadherin is a calcium-dependent cell adhesion molecule essential for maintaining the structural integrity and polarity of epithelial cells. By specifically binding to the extracellular domain of E-cadherin, this antibody is frequently utilized to study cell-cell adhesion mechanisms, the epithelial-mesenchymal transition (EMT) process, and tumor invasion and metastasis. In various cancers, the downregulation or loss of E-cadherin is considered a key hallmark of malignant progression and metastasis.
In vitro
In immunofluorescence studies, Anti-CDH1/E-cadherin/CD324 Antibody showed strong and specific reactivity with epithelial tissues, such as the lining of the intestine and kidney tubules, localizing primarily to the cell-cell interface of the plasma membrane [1].
In vivo
In mouse embryo assays, the addition of Anti-CDH1/E-cadherin/CD324 Antibody (anti-uvomorulin) to 8-cell stage embryos caused complete decompaction within 2-4 hours, demonstrating that the antibody effectively disrupts the calcium-dependent cell-cell adhesion required for blastocyst formation [1].
Reactivity
Human
Application
FACS
Functional assay
Antibody Type
Monoclonal
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Uniprot ID
TargetCDH1/E-cadherin/CD324
Chemical Properties
Antibody Information
IsotypeIgG1
Storage & Solubility Information
Storagestore at low temperature | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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