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Berberine ursodeoxycholate

Name: Berberine ursodeoxycholate
Brand: TargetMol
SKU: T67974
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67974Cas No. 1868138-66-2

Alias HTD1801, BUDCA

Berberine ursodeoxycholate (HTD1801) is an orally effective hypolipidemic agent, an ionic salt of Berberine and Ursodeoxycholic acid.Berberine ursodeoxycholate has a wide range of metabolic activity and significantly reduces liver fat content. Berberine ursodeoxycholate has been used in studies of hyperlipidemia, non-alcoholic steatohepatitis (NASH) and diabetes.

Berberine ursodeoxycholate

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Purity: 99.43%

Catalog No. T67974Alias HTD1801, BUDCACas No. 1868138-66-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
2 mg	$45	In Stock	In Stock
5 mg	$73	In Stock	In Stock
10 mg	$118	In Stock	In Stock
25 mg	$237	In Stock	In Stock
50 mg	$378	In Stock	In Stock
100 mg	$569	In Stock	In Stock
500 mg	$1,190	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.43%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Berberine ursodeoxycholate (HTD1801) is an orally effective hypolipidemic agent, an ionic salt of Berberine and Ursodeoxycholic acid.Berberine ursodeoxycholate has a wide range of metabolic activity and significantly reduces liver fat content. Berberine ursodeoxycholate has been used in studies of hyperlipidemia, non-alcoholic steatohepatitis (NASH) and diabetes.
In vivo	Berberine ursodeoxycholate (BUDCA) tested in this phase 2 study (1000 mg twice a day) results in a significant reduction in liver fat content after 18 weeks of treatment. This improvement in liver fat content is associated with improvement in glycemic control, the apparent improvement in hepatic inflammation and injury with reductions in serum levels of liver associated enzymes, significant weight loss, and modest reductions in serum lipid levels.[1]
Synonyms	HTD1801, BUDCA

Chemical Properties

Molecular Weight	727.93
Formula	C₄₄H₅₇NO₈
Cas No.	1868138-66-2
Smiles	COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC.[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC([O-])=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45.45 mg/mL (62.44 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3738 mL	6.8688 mL	13.7376 mL	68.6879 mL
5 mM	0.2748 mL	1.3738 mL	2.7475 mL	13.7376 mL
10 mM	0.1374 mL	0.6869 mL	1.3738 mL	6.8688 mL
20 mM	0.0687 mL	0.3434 mL	0.6869 mL	3.4344 mL
50 mM	0.0275 mL	0.1374 mL	0.2748 mL	1.3738 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc