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Berberine ursodeoxycholate

Catalog No. T67974 CAS 1868138-66-2

Synonyms: HTD1801, BUDCA

Berberine ursodeoxycholate (HTD1801) is an orally effective hypolipidemic agent, an ionic salt of Berberine and Ursodeoxycholic acid.Berberine ursodeoxycholate has a wide range of metabolic activity and significantly reduces liver fat content. Berberine ursodeoxycholate has been used in studies of hyperlipidemia, non-alcoholic steatohepatitis (NASH) and diabetes.

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Berberine ursodeoxycholate Chemical Structure

Berberine ursodeoxycholate, CAS 1868138-66-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
2 mg	In stock	$ 45.00
5 mg	In stock	$ 73.00
10 mg	In stock	$ 118.00
25 mg	In stock	$ 237.00
50 mg	In stock	$ 378.00
100 mg	In stock	$ 569.00
500 mg	In stock	$ 1,190.00

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Purity: 100%

Biological Description

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Description

In vivo

Berberine ursodeoxycholate (BUDCA) tested in this phase 2 study (1000 mg twice a day) results in a significant reduction in liver fat content after 18 weeks of treatment. This improvement in liver fat content is associated with improvement in glycemic control, the apparent improvement in hepatic inflammation and injury with reductions in serum levels of liver associated enzymes, significant weight loss, and modest reductions in serum lipid levels.[1]

Synonyms	HTD1801, BUDCA
Molecular Weight	217.69
Formula	C6H8CuN3O2
CAS No.	1868138-66-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6.9 mg/mL (9.5 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Harrison SA, et al. A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes. Nat Commun. 2021;12(1):5503. 2. Di Bisceglie AM, et al. Pharmacokinetics and pharmacodynamics of HTD1801 (berberine ursodeoxycholate, BUDCA) in patients with hyperlipidemia. Lipids Health Dis. 2020;19(1):239.

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Keywords

Berberine ursodeoxycholate 1868138-66-2 HTD1801 HTD-1801 BUDCA HTD 1801 inhibitor inhibit

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