Shopping Cart

Your shopping cart is currently empty

Sarafloxacin hydrochloride

Name: Sarafloxacin hydrochloride
Brand: TargetMol
SKU: T1107
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T1107Cas No. 91296-87-6

Alias Sarafloxacin HCl, A-56620 HCl, A-56620 (hydrochloride)

Sarafloxacin hydrochloride (A-56620 (hydrochloride)), a quinolone antibiotic drug, is a hydrochloride salt form of sarafloxacin.

Sarafloxacin hydrochloride

Copy Product Info

😃Good

Purity: 97.44%

Catalog No. T1107Alias Sarafloxacin HCl, A-56620 HCl, A-56620 (hydrochloride)Cas No. 91296-87-6

Sarafloxacin hydrochloride (A-56620 (hydrochloride)), a quinolone antibiotic drug, is a hydrochloride salt form of sarafloxacin.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$35	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:97.44%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Sarafloxacin hydrochloride AI Summary

Sarafloxacin hydrochloride exhibits potent in vitro antibacterial activity against a wide range of bacteria, including Staphylococcus aureus, Staphylococcus epidermis, Streptococcus faecium, Streptococcus pyogenes, Escherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter, with minimal inhibitory concentrations (MIC) ranging from 0.02 to 1.56 µg/mL. The compound also demonstrates significant in vivo antibacterial efficacy against systemic infections by Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa in mice, with effective dose (ED50) values ranging from 0.6 to 21.4 mg/kg when administered subcutaneously or orally. Additionally, Sarafloxacin hydrochloride shows inhibition against various enzyme and receptor targets, including Lamin A splicing, HSD17B4, JMJD2E, ALDH1A1, HPGD, and the vitamin D receptor (VDR), with potencies ranging from 2238.7 nM to 100000.0 nM. It also acts as a delayed death inhibitor of the malarial parasite plastid and inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) under varying conditions, with potencies between 14581.0 nM and 23715.0 nM. Furthermore, Sarafloxacin hydrochloride exhibits antiviral properties, including inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentration after 48 hours, as well as protease inhibition against the SARS-CoV-2 3CL-Pro protease, although these activities show variable inhibition percentages. The compound also demonstrates the ability to inhibit sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells with inhibition rates of 109.55% and 115.57%, respectively, at an equimolar concentration of 10 µM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Sarafloxacin hydrochloride (A-56620 (hydrochloride)), a quinolone antibiotic drug, is a hydrochloride salt form of sarafloxacin.
Synonyms	Sarafloxacin HCl, A-56620 HCl, A-56620 (hydrochloride)

Chemical Properties

Molecular Weight	421.83
Formula	C₂₀H₁₈ClF₂N₃O₃
Cas No.	91296-87-6
Smiles	Cl.OC(=O)C1=CN(C2=CC=C(F)C=C2)C2=CC(N3CCNCC3)=C(F)C=C2C1=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.5 mg/mL (13.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3706 mL	11.8531 mL	23.7062 mL	118.5312 mL
5 mM	0.4741 mL	2.3706 mL	4.7412 mL	23.7062 mL
10 mM	0.2371 mL	1.1853 mL	2.3706 mL	11.8531 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc