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Talarozole (R enantiomer)

Name: Talarozole (R enantiomer)
Brand: TargetMol
SKU: T13422L
Rating: 4.5 (1 reviews)

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Catalog No. T13422LCas No. 870093-23-5

Alias Talarozole R enantiomer, (R)-Talarozole

Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated degradation of endogenous all-trans retinoic acid.

Talarozole (R enantiomer)

😃Good

Catalog No. T13422LAlias Talarozole R enantiomer, (R)-TalarozoleCas No. 870093-23-5

Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated degradation of endogenous all-trans retinoic acid.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated degradation of endogenous all-trans retinoic acid.
In vitro	Talarozole R enantiomer treatment increased the mRNA expression of CRABP2, KRT4, CYP26A1, and CYP26B1 dose-dependently, and decreased the expression of KRT2 and IL-1alpha compared with vehicle-treated skin. No mRNA change in retinol-metabolizing enzymes was obtained. There was no induction of epidermal thickness or overt skin inflammation in talarozole-treated skin. Immunofluorescence analysis confirmed the upregulation of KRT4 protein, but no upregulation of CYP26A1 and CYP26B1 expression was detected [1] [2].
In vivo	Talarozole R enantiomer slightly diffused into the skin only when dissolved in propylene glycol, isopropyl myristate, or ethanol. Although only 0.1% of the dose applied was found in the skin itself after 12-24 h, this was sufficient to achieve local concentrations well above the half-maximal inhibitory concentration value for talarozole. The distribution of talarozole within the skin was investigated: 80% was located in the epidermis, while the remaining 20% was found in the dermis [3].
Synonyms	Talarozole R enantiomer, (R)-Talarozole

Chemical Properties

Molecular Weight	377.51
Formula	C₂₁H₂₃N₅S
Cas No.	870093-23-5
Smiles	[C@@H](C(CC)CC)(C1=CC=C(NC2=NC=3C(S2)=CC=CC3)C=C1)N4C=NC=N4
Relative Density.	1.26 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 51 mg/mL (135.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6489 mL	13.2447 mL	26.4894 mL	132.4468 mL
5 mM	0.5298 mL	2.6489 mL	5.2979 mL	26.4894 mL
10 mM	0.2649 mL	1.3245 mL	2.6489 mL	13.2447 mL
20 mM	0.1324 mL	0.6622 mL	1.3245 mL	6.6223 mL
50 mM	0.0530 mL	0.2649 mL	0.5298 mL	2.6489 mL
100 mM	0.0265 mL	0.1324 mL	0.2649 mL	1.3245 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc