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PU-H71

Name: PU-H71
Brand: TargetMol
SKU: T6960
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6960Cas No. 873436-91-0

PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.

PU-H71

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Purity: 99.93%

Catalog No. T6960Cas No. 873436-91-0

PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	-	In Stock
5 mg	$55	-	In Stock
10 mg	$87	-	In Stock
25 mg	$139	-	In Stock
50 mg	$198	-	In Stock
1 mL x 10 mM (in DMSO)	$82	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.
Targets&IC50	HSP90:51 nM
In vitro	PU-H71(1 μ M) potently inhibits the growth of triple negative breast cancer (TNBC) cell lines MDA-MB-468, MDA-MB-231, and HCC-1806, with IC50 values of 65, 140, and 87 nM, respectively. PU-H71(1 μ M) kills 80%, 65%, and 80% of MDA-MB-468, MDA-MB-231, and HCC-1806 cells, respectively[1].
In vivo	MDA-MB-231 model treated with PU-H71 at a dose of 75 mg/kg was 100% fully effective. After 37 days of treatment, tumor was replaced by scar tissue, accompanied by a reduction in many proliferative and anti apoptotic molecules, such as EGFR, HER3, Raf-1, Akt, and p-Akt, which decreased by 80%, 95%, 99%, 80%, and 65%, respectively. PU-H71 (75 mg/kg, three times a week) inhibits tumor growth by 96%, reduces tumor cell proliferation by 60%, decreases activated Akt associated with survival and high invasive potential by 85%, and increases apoptosis by 6-fold[1].

Chemical Properties

Molecular Weight	512.37
Formula	C₁₈H₂₁IN₆O₂S
Cas No.	873436-91-0
Smiles	CC(C)NCCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)ncnc12
Relative Density.	1.84 g/cm3

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 46.1 mg/mL (89.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9517 mL	9.7586 mL	19.5171 mL	97.5857 mL
5 mM	0.3903 mL	1.9517 mL	3.9034 mL	19.5171 mL
10 mM	0.1952 mL	0.9759 mL	1.9517 mL	9.7586 mL
20 mM	0.0976 mL	0.4879 mL	0.9759 mL	4.8793 mL
50 mM	0.0390 mL	0.1952 mL	0.3903 mL	1.9517 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc