G3-C12

Name: G3-C12
Brand: TargetMol
SKU: T11346
Rating: 4.5 (1 reviews)

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Catalog No. T11346Cas No. 848301-94-0

G3-C12 shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.

G3-C12

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Catalog No. T11346Cas No. 848301-94-0

G3-C12 shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
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500 mg	Inquiry	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description	G3-C12 shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.
Targets&IC50	GAL3:(kd)88 nM
In vitro	G3-C12, an opolymer incorporating N-(2-hydroxypropyl)methacrylamide (HPMA), demonstrates potent and selective affinity for colorectal cancer (CRC) cells overexpressing galectin-3, exhibiting enhanced targeting capabilities compared to its galactose-based counterparts. As a galectin-3 binding peptide, G3-C12 has a high affinity (Kd) of 88 nM but lacks affinity for other members of the galectin family or unrelated lectins.

Chemical Properties

Molecular Weight	1758.99
Formula	C₇₄H₁₁₅N₂₃O₂₃S₂
Cas No.	848301-94-0
Smiles	CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Relative Density.	1.58 g/cm3 (Predicted)
Sequence	Ala-Asn-Thr-Pro-Cys-Gly-Pro-Tyr-Thr-His-Asp-Cys-Pro-Val-Lys-Arg
Sequence Short	ANTPCGPYTHDCPVKR

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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