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Atg4B-IN-2

Name: Atg4B-IN-2
Brand: TargetMol
SKU: T60967
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60967Cas No. 2765008-88-4

Atg4B-IN-2. A potent, selective Atg4B inhibitor with anticancer activity, inhibits both Atg4B and PLA2, enabling autophagy that counteracts the anticancer activity of anti-desiccation-resistant prostate cancer drugs.

Atg4B-IN-2

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Purity: 98.86%

Catalog No. T60967Cas No. 2765008-88-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	In Stock	In Stock
5 mg	$160	In Stock	In Stock
10 mg	$266	In Stock	In Stock
25 mg	$458	In Stock	In Stock
50 mg	$642	In Stock	In Stock
100 mg	$861	6-8 weeks	6-8 weeks
200 mg	$1,160	6-8 weeks	6-8 weeks

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Expected start date of shipmentUSA Warehouse [1-2 days] Global Warehouse [5-7 days]

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Purity:98.86%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Atg4B-IN-2. A potent, selective Atg4B inhibitor with anticancer activity, inhibits both Atg4B and PLA2, enabling autophagy that counteracts the anticancer activity of anti-desiccation-resistant prostate cancer drugs.
Targets&IC50	Atg4B:3.1 μM (Ki), PLA2:3.5 μM, Atg4B:11 μM
In vitro	In a dose-dependent manner, Atg4B-IN-2 (compound 21f) (1-10 μM; 2 hours) restores p62 expression in cells treated with amino acid-free (AF) conditions [1]. At concentrations of 1 and 5 μM (2 hours), Atg4B-IN-2 moderately decreases autophagic vesicles at 1 μM and almost completely inhibits autophagy at 5 μM [1]. At a concentration of 5 μM (2 hours), Atg4B-IN-2 inhibits Abi-induced autophagy, significantly enhances apoptotic cell death, and increases sensitivity to Abi [1].

Chemical Properties

Molecular Weight	330.46
Formula	C₂₁H₃₀O₃
Cas No.	2765008-88-4
Smiles	C(/C=C/C(O)=O)(=O)C1=CC=C(CCCCCCCCCCC)C=C1
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (242.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0261 mL	15.1304 mL	30.2608 mL	151.3042 mL
5 mM	0.6052 mL	3.0261 mL	6.0522 mL	30.2608 mL
10 mM	0.3026 mL	1.5130 mL	3.0261 mL	15.1304 mL
20 mM	0.1513 mL	0.7565 mL	1.5130 mL	7.5652 mL
50 mM	0.0605 mL	0.3026 mL	0.6052 mL	3.0261 mL
100 mM	0.0303 mL	0.1513 mL	0.3026 mL	1.5130 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc