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Anti-SHC1 Monoclonal Antibody (6G814)
(Synonyms: SHCA, SHC) Copy Product Info
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Synonyms: SHCA, SHC
Catalog No. TMAC-03736 Copy Product Info
🥰Excellent
Anti-SHC1 Monoclonal Antibody (6G814) is a Mouse antibody targeting SHC1. Anti-SHC1 Monoclonal Antibody (6G814) can be used in WB,IF,FCM.
Anti-SHC1 Monoclonal Antibody
(6G814)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 µL | $297 | 7-10 days | 7-10 days | |
| 100 µL | $427 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-SHC1 Monoclonal Antibody (6G814) is a Mouse antibody targeting SHC1. Anti-SHC1 Monoclonal Antibody (6G814) can be used in WB,IF,FCM. |
| Synonyms | SHCA, SHC |
| Ig Type | IgG1 |
| Clone | 6G814 |
| Reactivity | Human,Mouse |
| Verified Activity | 1. Western blot analysis of SHC1 on NIH/3T3?cell lysate using anti-SHC1 antibody at 1/1,000 dilution. 2. ICC staining SHC1 (green) and Actin filaments (red) in A431 cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 3. Flow cytometric analysis of NIH/3T3 cells with SHC1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).  , , |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human SHC1 (AA: 385-495) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | SHC1 |
| Gene ID | |
| Protein Name | SHC-transforming protein 1 |
| Uniprot ID |
| Molecular Weight | Theoretical: 62.8 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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