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Anti-Shc Antibody (2E265)
(Synonyms: Src homology 2 domain-containing-transforming protein C1, SHC-transforming protein A, SHC-transforming protein 3, SHC-transforming protein 1, SHCA, SHC1_HUMAN, SHC1, SHC transforming protein 1, SHC transforming protein, SHC adaptor protein 1, SHC A, SHC 1, SHC (Src homology 2 domain containing) transforming protein 1, Shc, SH2 domain protein C1, p66SHC, p66, FLJ26504) Copy Product Info
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Synonyms: Src homology 2 domain-containing-transforming protein C1, SHC-transforming protein A, SHC-transforming protein 3, SHC-transforming protein 1, SHCA, SHC1_HUMAN, SHC1, SHC transforming protein 1, SHC transforming protein, SHC adaptor protein 1, SHC A, SHC 1, SHC (Src homology 2 domain containing) transforming protein 1, Shc, SH2 domain protein C1, p66SHC, p66, FLJ26504
Catalog No. TMAC-03736 Copy Product Info
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Anti-Shc Antibody (2E265) is a Mouse antibody targeting Shc. Anti-Shc Antibody (2E265) can be used in FCM,ICC,WB.
Anti-Shc Antibody
(2E265)
(2E265)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $297 | 7-10 days | 7-10 days | |
| 100 μL | $427 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-Shc Antibody (2E265) is a Mouse antibody targeting Shc. Anti-Shc Antibody (2E265) can be used in FCM,ICC,WB. |
| Synonyms | Src homology 2 domain-containing-transforming protein C1, SHC-transforming protein A, SHC-transforming protein 3, SHC-transforming protein 1, SHCA, SHC1_HUMAN, SHC1, SHC transforming protein 1, SHC transforming protein, SHC adaptor protein 1, SHC A, SHC 1, SHC (Src homology 2 domain containing) transforming protein 1, Shc, SH2 domain protein C1, p66SHC, p66, FLJ26504 |
| Clone | 2E265 |
| Reactivity | Human,Mouse |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC: 1:50-200; ICC: 1:50-200; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus activating mitogenic, as well as other, responses. Critical components of this process include adapter proteins such as Shc and IRS-1 that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to physically link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major insulin receptor substrate (4-7). Shc also participates in insulin signaling by linking the insulin receptor to Ras by forming complexes with the adapter protein GRB2 and Sos independently of IRS-1. A protein immunologically related to IRS-1, originally designated 4PS and now known as IRS-2, was shown to become highly tyrosine phosphorylated in response to IL-4 or IGF-1 in cells lacking IRS-1. An additional member of this family of signaling intermediates, Shb, is a SH2-containing protein with characteristic proline-rich domains. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 63 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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