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Anti-Phospho-CRMP2 (Thr514+Ser518) Polyclonal Antibody
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Catalog No. TMAB-10548
Anti-Phospho-CRMP2 (Thr514+Ser518) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CRMP2 (Thr514+Ser518). Anti-Phospho-CRMP2 (Thr514+Ser518) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-CRMP2 (Thr514+Ser518) Polyclonal Antibody
Anti-Phospho-CRMP2 (Thr514+Ser518) Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-10548
Anti-Phospho-CRMP2 (Thr514+Ser518) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CRMP2 (Thr514+Ser518). Anti-Phospho-CRMP2 (Thr514+Ser518) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-Phospho-CRMP2 (Thr514+Ser518) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CRMP2 (Thr514+Ser518). Anti-Phospho-CRMP2 (Thr514+Ser518) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Pig,Cow,Horse,Sheep) |
| Verified Activity | 1. Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (Phospho-CRMP2 (Thr514+Ser518)) Polyclonal Antibody, Unconjugated (TMAB-10548) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. 2. Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (Phospho-CRMP2 (Thr514+Ser518)) Polyclonal Antibody, Unconjugated (TMAB-10548) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. 3. Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (Phospho-CRMP2 (Thr514+Ser518)) Polyclonal Antibody, Unconjugated (TMAB-10548) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Cell projection, growth cone. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. |
| Tissue Specificity | Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The CRMPs appear to play a complex role in axon growth as well as microtubule dynamics and axon induction. CRMPs localize to the lamellipodia and filopodia of axonal growth cones, suggesting a role in axon guidance. Moreover, CRMP2 is upregulated after axotomy, and appears to increase the formation of axon-type processes from hippocampal neurons. CRMP2 has been reported to bind tubulin dimers directly and modulate microtubule assembly. CRMPs have also been implicated in the pathogenesis of a paraneoplastic neurologic syndrome. Interaction studies have implicated phospholipase D2 (PLD2), the cytosolic tyrosine kinase Fes, and intersectin in CRMP function. Hyperphosphorylation of CRMP2 is an early event in the progression of Alzheimer's disease. |
| Immunogen | KLH conjugated synthesised phosphopeptide: human CRMP2 around the phosphorylation site of Thr514+Ser518 |
| Antigen Species | Human |
| Gene Name | DPYSL2 |
| Gene ID | |
| Protein Name | Dihydropyrimidinase-related protein 2 |
| Uniprot ID | |
| Function | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). |
| Molecular Weight | Theoretical: 62 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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