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Anti-SAMHD1 Antibody (8T611)
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Catalog No. TMAC-03684
Alias SBBI88, Samhd 1, SAMH1_HUMAN, SAM domain and HD domain-containing protein 1, SAM domain and HD domain containing protein 1, SAM domain and HD domain 1, OTTHUMP00000030889, MOP-5, MOP5, MOP 5, Monocyte protein 5, Mg11, HDDC1, HD domain containing 1, dNTPase, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, Dendritic cell-derived IFNG-induced protein, Dendritic cell derived IFNG induced protein, DCIP, CHBL2
Anti-SAMHD1 Antibody (8T611) is a Rabbit antibody targeting SAMHD1. Anti-SAMHD1 Antibody (8T611) can be used in WB,ICC,IHC,FCM.
Anti-SAMHD1 Antibody (8T611)
Anti-SAMHD1 Antibody (8T611)
😃Good
Catalog No. TMAC-03684Alias SBBI88, Samhd 1, SAMH1_HUMAN, SAM domain and HD domain-containing protein 1, SAM domain and HD domain containing protein 1, SAM domain and HD domain 1, OTTHUMP00000030889, MOP-5, MOP5, MOP 5, Monocyte protein 5, Mg11, HDDC1, HD domain containing 1, dNTPase, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, Dendritic cell-derived IFNG-induced protein, Dendritic cell derived IFNG induced protein, DCIP, CHBL2
Anti-SAMHD1 Antibody (8T611) is a Rabbit antibody targeting SAMHD1. Anti-SAMHD1 Antibody (8T611) can be used in WB,ICC,IHC,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $298 | 7-10 days | |
| 100 μL | $498 | 7-10 days |
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| Description | Anti-SAMHD1 Antibody (8T611) is a Rabbit antibody targeting SAMHD1. Anti-SAMHD1 Antibody (8T611) can be used in WB,ICC,IHC,FCM. |
| Synonyms | SBBI88, Samhd 1, SAMH1_HUMAN, SAM domain and HD domain-containing protein 1, SAM domain and HD domain containing protein 1, SAM domain and HD domain 1, OTTHUMP00000030889, MOP-5, MOP5, MOP 5, Monocyte protein 5, Mg11, HDDC1, HD domain containing 1, dNTPase, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, Dendritic cell-derived IFNG-induced protein, Dendritic cell derived IFNG induced protein, DCIP, CHBL2 |
| Ig Type | IgG |
| Clone | 8T611 |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of SAMHD1 on THP-1 cell lysate using anti-SAMHD1 antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-SAMHD1 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-SAMHD1 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-SAMHD1 antibody. Counter stained with hematoxylin. 5. ICC staining SAMHD1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining SAMHD1 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. ICC staining SAMHD1 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 8. Flow cytometric analysis of K562 cells with SAMHD1 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC: 1:50-200; ICC: 1:100-500; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | SAM domain and HD domain-containing protein 1 is a protein that in humans is encoded by the SAMHD1 gene. SAMHD1 is a cellular enzyme, responsible for blocking replication of HIV in dendritic cells, macrophages and monocytes. It is an enzyme that exhibits phosphohydrolase activity, converting deoxynucleoside triphosphates (dNTPs) to inorganic phosphate (iPPP) and a 2'-deoxynucleoside (i.e. deoxynucleosides without a phosphate group). In doing so, SAMHD1 depletes the pool of dNTPs available to a reverse transcriptase for viral cDNA synthesis and thus prevents viral replication. SAMHD1 has also shown nuclease activity. Although a ribonuclease activity was described to be required for HIV-1 restriction, recent data confirmed that SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 72 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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