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ethyl rosmarinate

Name: ethyl rosmarinate
Brand: TargetMol
SKU: TN6784
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN6784Cas No. 174591-47-0

ethyl rosmarinate inhibit the activity of tyrosinase, α-glucosidase, and matrix metalloproteinase-1 (MMP-1).

ethyl rosmarinate

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Purity: 99.97%

Catalog No. TN6784Cas No. 174591-47-0

ethyl rosmarinate inhibit the activity of tyrosinase, α-glucosidase, and matrix metalloproteinase-1 (MMP-1).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
5 mg	$163	In Stock	In Stock
10 mg	$255	In Stock	In Stock
25 mg	$432	In Stock	In Stock
50 mg	$639	In Stock	In Stock
100 mg	$910	-	In Stock
1 mL x 10 mM (in DMSO)	$172	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Color:White

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COA HNMR LCMS

Product Introduction

ethyl rosmarinate AI Summary

ethyl rosmarinate inhibits the p56lck SH2 domain with an IC50 value of 91000.0 nM. It also targets T-cell antigen receptor-induced IL-2 expression, demonstrating a 22.7% inhibition in Jurkat cell activation at a 10 µM concentration, as evidenced by a luciferase assay. In human HepG2 cells, ethyl rosmarinate inhibits TNF-alpha-induced NF-kappaB transactivation by 57.0% when preincubated at 20 µM for one hour prior to TNF-alpha challenge, measured via a luciferase reporter gene assay after an additional hour. Furthermore, the compound shows anti-inflammatory properties in LPS-stimulated mouse RAW264.7 cells by reducing PGE2 production, with an IC50 value of 4300.0 nM. The compound also has a partition coefficient, log P, of 1.499..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	ethyl rosmarinate inhibit the activity of tyrosinase, α-glucosidase, and matrix metalloproteinase-1 (MMP-1).
Targets&IC50	Tyrosinase:0.28mM, α-glucosidase:0.29mM, MMP1:

Chemical Properties

Molecular Weight	388.37
Formula	C₂₀H₂₀O₈
Cas No.	174591-47-0
Smiles	C([C@@H](OC(/C=C/C1=CC(O)=C(O)C=C1)=O)C(OCC)=O)C2=CC(O)=C(O)C=C2
Relative Density.	1.413 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (141.62 mM), Sonication is recommended.

H2O: 10 mg/mL (25.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5749 mL	12.8743 mL	25.7486 mL	128.7432 mL
5 mM	0.5150 mL	2.5749 mL	5.1497 mL	25.7486 mL
10 mM	0.2575 mL	1.2874 mL	2.5749 mL	12.8743 mL
20 mM	0.1287 mL	0.6437 mL	1.2874 mL	6.4372 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0515 mL	0.2575 mL	0.5150 mL	2.5749 mL
100 mM	0.0257 mL	0.1287 mL	0.2575 mL	1.2874 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc