Shopping Cart
Remove All
Your shopping cart is currently empty
SEW2871
Copy Product Info
🥰Excellent
Catalog No. T2171Cas No. 256414-75-2
Alias SEW2871
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, and inflammation. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.
SEW2871
Copy Product Info🥰Excellent
Purity: 99.96%
Catalog No. T2171Alias SEW2871Cas No. 256414-75-2
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, and inflammation. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $48 | In Stock | In Stock | |
| 2 mg | $76 | In Stock | In Stock | |
| 5 mg | $153 | In Stock | In Stock | |
| 10 mg | $263 | In Stock | In Stock | |
| 25 mg | $436 | In Stock | In Stock | |
| 50 mg | $643 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $148 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.96%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
SEW2871 AI Summary
SEW2871 exhibits a multifaceted bioactivity profile. It shows high potency in displacing [33P]sphingosine 1 phosphate from the human S1P1 receptor (IC50 = 37.0 nM) and demonstrates moderate activity on the S1P5 receptor (IC50 = 4600.0 nM). It does not significantly affect the S1P2, S1P3, and S1P4 receptors (IC50 > 10000.0 nM). The compound also acts as an inhibitor for 15-human lipoxygenase and Polymerase Kappa with IC50 values of 39810.7 nM and 21192.3 nM, respectively. It has immunosuppressive effects in Lewis rats, reducing peripheral lymphocyte count by 66% at a 30 mg/kg dose orally after 24 hours, and achieves a plasma concentration of 1100.0 ng/ml. Additionally, SEW2871 exhibits agonist activity at the human S1P1 receptor (EC50 = 270.0 nM) and modest activity at the human S1P3 receptor (EC50 > 25000.0 nM). The antiviral potential of SEW2871 includes inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM, as well as inhibition of the SARS-CoV-2 3CL-Pro protease (7.276% inhibition at 20 µM). The compound shows variable effects on cell viability depending on the cell type and demonstrates inhibitory effects on GPCR beta-arrestin recruitment for multiple receptors, with a stimulating effect on GPR119. Additionally, it modulates the thermal stability of different protein domains and affects the enzymatic activity of human HDAC6 in a substrate-dependent manner. This intricate bioactivity suggests potential applications in both immunosuppressive therapies and antiviral treatments..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, and inflammation. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling. |
| Targets&IC50 | S1P1:13.8 nM (EC50) |
| Synonyms | SEW2871 |
| Molecular Weight | 440.36 |
| Formula | C20H10F6N2OS |
| Cas No. | 256414-75-2 |
| Smiles | FC(F)(F)c1sc(cc1-c1ccccc1)-c1nc(no1)-c1cccc(c1)C(F)(F)F |
| Relative Density. | 1.415 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 8.8 mg/mL (19.98 mM), Sonication is recommended. | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.27 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
| |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
SEW-2871SEW?2871SEW2871SEW 2871S1PReceptorS1P1S1P ReceptorProtein kinase BPKBorally activeLysophospholipid ReceptorLX-2 cellsLPLReceptorLPL ReceptorLPLliver fibrosisischaemia-reperfusion injuryInhibitorinhibitExtracellular signal regulated kinasesERKdiabetesCrohn's diseasecolitisAlzheimer's diseaseAkt
Preview
Related Tags: buy SEW2871 | purchase SEW2871 | SEW2871 cost | order SEW2871 | SEW2871 chemical structure | SEW2871 formula | SEW2871 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.