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Anti-SCN8A/Nav1.6 Polyclonal Antibody

Catalog No. TMAB-12587 Copy Product Info
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Anti-SCN8A/Nav1.6 Polyclonal Antibody is a Rabbit antibody targeting SCN8A/Nav1.6. Anti-SCN8A/Nav1.6 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-SCN8A/Nav1.6 Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAB-12587

Anti-SCN8A/Nav1.6 Polyclonal Antibody is a Rabbit antibody targeting SCN8A/Nav1.6. Anti-SCN8A/Nav1.6 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-SCN8A/Nav1.6 Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2217-10 days7-10 days
100 μL$3747-10 days7-10 days
200 μL$5287-10 days7-10 days
In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-SCN8A/Nav1.6 Polyclonal Antibody is a Rabbit antibody targeting SCN8A/Nav1.6. Anti-SCN8A/Nav1.6 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Mouse (predicted:Human,Rat,Dog,Pig,Cow,Rabbit)
Verified Activity
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (SCN8A/Nav1.6) Polyclonal Antibody, Unconjugated (TMAB-12587) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining.
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Cytoplasm, perinuclear region.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundMediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human SCN8A/Nav1.6
Antigen Species
Human
Gene Name
SCN8A
Gene ID
Protein Name
Sodium channel protein type 8 subunit alpha
Uniprot ID
Function
Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.
Chemical Properties
Molecular WeightTheoretical: 220 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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