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PF-06882961

Name: PF-06882961
Brand: TargetMol
SKU: T12431
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12431Cas No. 2230198-02-2

Alias Danuglipron

PF-06882961 is an orally bioavailable glucagon-like peptide-1 receptor (GLP-1R) agonist.

PF-06882961

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Purity: 99.54%

Catalog No. T12431Alias DanuglipronCas No. 2230198-02-2

PF-06882961 is an orally bioavailable glucagon-like peptide-1 receptor (GLP-1R) agonist.

Pack Size	Price	Availability
1 mg	$42	In Stock
5 mg	$91	In Stock
10 mg	$158	In Stock
25 mg	$208	In Stock
50 mg	$266	In Stock
100 mg	$457	In Stock
1 mL x 10 mM (in DMSO)	$111	In Stock

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Batch Information

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Purity:99.54%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	PF-06882961 is an orally bioavailable glucagon-like peptide-1 receptor (GLP-1R) agonist.
In vivo	PF-06882961 shows mild to moderate damage to the heart, moderate to severe effects on the thymus gland (which helps with managing infection), mild to moderate stomach ulcers at the highest dose level given in the rat[3].
Synonyms	Danuglipron

Chemical Properties

Molecular Weight	555.6
Formula	C₃₁H₃₀FN₅O₄
Cas No.	2230198-02-2
Smiles	OC(C1=CC=C(N=C(CN2CCC(C3=NC(OCC4=CC=C(C#N)C=C4F)=CC=C3)CC2)N5C[C@H]6OCC6)C5=C1)=O
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (224.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7999 mL	8.9993 mL	17.9986 mL	89.9928 mL
5 mM	0.3600 mL	1.7999 mL	3.5997 mL	17.9986 mL
10 mM	0.1800 mL	0.8999 mL	1.7999 mL	8.9993 mL
20 mM	0.0900 mL	0.4500 mL	0.8999 mL	4.4996 mL
50 mM	0.0360 mL	0.1800 mL	0.3600 mL	1.7999 mL
100 mM	0.0180 mL	0.0900 mL	0.1800 mL	0.8999 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc