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N-Benzyllinolenamide

Name: N-Benzyllinolenamide
Brand: TargetMol
SKU: TN1965
Price: 78 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1965Cas No. 883715-18-2

Alias N-Benzyllinolenamide

N-Benzyllinolenamide is a natural product. It is an inhibitor of fatty acid amide hydrolase (FAAH, IC50 of 41.8 μM).

N-Benzyllinolenamide

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Purity: 99.92%

Catalog No. TN1965Alias N-BenzyllinolenamideCas No. 883715-18-2

N-Benzyllinolenamide is a natural product. It is an inhibitor of fatty acid amide hydrolase (FAAH, IC50 of 41.8 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$78	In Stock	In Stock
5 mg	$189	In Stock	In Stock
10 mg	$289	In Stock	In Stock
25 mg	$489	In Stock	In Stock
50 mg	$698	-	In Stock
100 mg	$968	-	In Stock
200 mg	$1,280	-	In Stock
1 mL x 10 mM (in DMSO)	$197	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.92%

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

N-Benzyllinolenamide AI Summary

N-Benzyllinolenamide demonstrates notable inhibitory activity against the recombinant human FAAH enzyme, exhibiting an IC50 value of 41800.0 nM. In fluorescence assays, the compound shows varying levels of FAAH inhibition from 14.5% to 75.6% depending on the concentration preincubated for 20 minutes. Additionally, it has a Ki value of 43960.0 nM and 8880.0 nM for human CB2 and CB1 receptors, respectively, indicating binding affinity for cannabinoid receptors. In human U937 cells, N-Benzyllinolenamide inhibits FAAH-mediated [ethanol-amine-1-3H]AEA hydrolysis with an IC50 value of 11480.0 nM and shows 53.0% efficacy in inhibiting [ethanol-amine-1-3H]AEA uptake, with an IC50 value of 84360.0 nM. Pharmacokinetically, when administered orally to Sprague-Dawley rats at a dose of 100 mg/kg, the compound has a half-life of 14.6 hours, an AUC of 265.76 ng.hr.mL-1, and reaches peak plasma concentration (Tmax) at 6 hours with a Cmax of 54.0 nM. Additionally, N-Benzyllinolenamide exhibits potent inhibition of recombinant soluble epoxide hydrolase (sEH) enzymes from mouse, rat, and human sources, with IC50 values of 28.0 nM, 23.0 nM, and 134.0 nM respectively, measured using MNPC in fluorescence-based assays. Overall, N-Benzyllinolenamide shows significant bioactivity in modulating endocannabinoid metabolism and interactions with cannabinoid receptors..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	N-Benzyllinolenamide is a natural product. It is an inhibitor of fatty acid amide hydrolase (FAAH, IC50 of 41.8 μM).
Targets&IC50	FAAH:41.8 μM
Synonyms	N-Benzyllinolenamide

Chemical Properties

Molecular Weight	367.57
Formula	C₂₅H₃₇NO
Cas No.	883715-18-2
Smiles	CC\C=C/C\C=C/C\C=C/CCCCCCCC(=O)NCc1ccccc1
Relative Density.	0.943±0.06 g/cm3 (20 °C,760 mmHg), Cal.

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (68.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.44 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7206 mL	13.6029 mL	27.2057 mL	136.0285 mL
5 mM	0.5441 mL	2.7206 mL	5.4411 mL	27.2057 mL
10 mM	0.2721 mL	1.3603 mL	2.7206 mL	13.6029 mL
20 mM	0.1360 mL	0.6801 mL	1.3603 mL	6.8014 mL
50 mM	0.0544 mL	0.2721 mL	0.5441 mL	2.7206 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc