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HeFi-1

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Catalog No. T9901A-1744

HeFi-1 is a mouse anti-CD30 IgG1 monoclonal antibody that targets the ligand-binding site on CD30. It can inhibit the growth of tumor cells with high CD30 expression and induce eosinophil apoptosis (apoptosis). HeFi-1 is applicable in research on cancer or inflammatory diseases, such as anaplastic large cell lymphoma (ALCL) and asthma.

HeFi-1

HeFi-1

😃Good
Catalog No. T9901A-1744
HeFi-1 is a mouse anti-CD30 IgG1 monoclonal antibody that targets the ligand-binding site on CD30. It can inhibit the growth of tumor cells with high CD30 expression and induce eosinophil apoptosis (apoptosis). HeFi-1 is applicable in research on cancer or inflammatory diseases, such as anaplastic large cell lymphoma (ALCL) and asthma.
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
HeFi-1 is a mouse anti-CD30 IgG1 monoclonal antibody that targets the ligand-binding site on CD30. It can inhibit the growth of tumor cells with high CD30 expression and induce eosinophil apoptosis (apoptosis). HeFi-1 is applicable in research on cancer or inflammatory diseases, such as anaplastic large cell lymphoma (ALCL) and asthma.
In vitro
HeFi-1 (0.1 ng/μL, 1 hour) can specifically bind to Karpas299 cells, achieving a binding rate of over 90%. At a concentration of 20 μg/mL for 48 hours, HeFi-1 significantly inhibits the proliferation of Karpas299 cells and induces G1 phase arrest. Additionally, HeFi-1 (20 μg/mL, 12-24 hours) significantly induces eosinophil apoptosis.
In vivo
Administered intravenously at a dose of HeFi-1 (100 μg) once a week for four weeks, the compound significantly prolongs the survival of SCID/NOD wild-type and FcRγ -/- Karpas299 lymphoma-bearing mice.
Chemical Properties
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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