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Acecainide hydrochloride

Name: Acecainide hydrochloride
Brand: TargetMol
SKU: T3575
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3575Cas No. 34118-92-8

Alias NAPA, ASL 601

Acecainide hydrochloride (NAPA) is the major hepatic metabolite of procainamide and its antiarrhythmic effects may lead to cardiotoxicity in renal failure.

Acecainide hydrochloride

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Purity: 99.81%

Catalog No. T3575Alias NAPA, ASL 601Cas No. 34118-92-8

Acecainide hydrochloride (NAPA) is the major hepatic metabolite of procainamide and its antiarrhythmic effects may lead to cardiotoxicity in renal failure.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$34	-	In Stock
10 mg	$55	-	In Stock
25 mg	$98	-	In Stock
50 mg	$163	-	In Stock
100 mg	$238	-	In Stock
200 mg	$353	-	In Stock
1 mL x 10 mM (in DMSO)	$43	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.81%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Acecainide hydrochloride AI Summary

Acecainide hydrochloride exhibits a broad spectrum of bioactivities. It inhibits the expression of the SMN2 splice variant, the interaction between thyroid hormone receptor and steroid receptor coregulator 2, Bloom's syndrome helicase, DNA Polymerase Beta, GCN5L2, Histone Lysine Methyltransferase G9a, and Nrf2. Additionally, it blocks the interaction between CBF-beta and RUNX1, potentially treating Acute Myeloid Leukemia, and targets malarial parasite plastid and Marburg Virus binding or entry into cells. It shows potential for treating Ataxia-Telangiectasia and inhibits human hERG channel activity and Hepatitis C Virus. Acecainide hydrochloride activates Cytochrome P450 3A4. The compound also exhibits significant transporter inhibition, with a 70.32% inhibition of sodium fluorescein uptake in OATP1B1-transfected cells and a 90.6% inhibition in OATP1B3-transfected cells at a 10 µM concentration. It has demonstrated antiarrhythmic activity, as evidenced by its protection against chloroform-induced ventricular fibrillation in ICR mice with an effective dose (ED50) of 110.0 mg/kg intraperitoneally (ip). Moreover, Acecainide hydrochloride shows antiviral properties against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 cells by 2.23% at 10 µM after 48 hours and VERO-6 cells with a rate of -0.03%. It also inhibits SARS-CoV-2 3CL-Pro protease activity by 12.27% at a concentration of 20 µM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Acecainide hydrochloride (NAPA) is the major hepatic metabolite of procainamide and its antiarrhythmic effects may lead to cardiotoxicity in renal failure.
Synonyms	NAPA, ASL 601

Chemical Properties

Molecular Weight	313.83
Formula	C₁₅H₂₄ClN₃O₂
Cas No.	34118-92-8
Smiles	Cl.CCN(CC)CCNC(=O)c1ccc(NC(C)=O)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (79.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1864 mL	15.9322 mL	31.8644 mL	159.3219 mL
5 mM	0.6373 mL	3.1864 mL	6.3729 mL	31.8644 mL
10 mM	0.3186 mL	1.5932 mL	3.1864 mL	15.9322 mL
20 mM	0.1593 mL	0.7966 mL	1.5932 mL	7.9661 mL
50 mM	0.0637 mL	0.3186 mL	0.6373 mL	3.1864 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc