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4-Isopropoxybenzoic acid

Name: 4-Isopropoxybenzoic acid
Brand: TargetMol
SKU: T24977
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24977Cas No. 13205-46-4

Alias AI3-12104, AI312104, AI3 12104

4-Isopropoxybenzoic acid (AI3 12104) is a Centromere-Associated Protein E inhibitor.

4-Isopropoxybenzoic acid

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Purity: 99.88%

Catalog No. T24977Alias AI3-12104, AI312104, AI3 12104Cas No. 13205-46-4

4-Isopropoxybenzoic acid (AI3 12104) is a Centromere-Associated Protein E inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$44	In Stock	In Stock
1 g	$56	In Stock	In Stock
5 g	$133	-	In Stock
10 g	$198	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

4-Isopropoxybenzoic acid AI Summary

4-Isopropoxybenzoic acid exhibits a range of bioactivities, including the inhibition of key interactions such as the MLL CXXC domain with DNA, Heat Shock Factor 1 (HSF1), and HP1-beta Chromodomain with methylated histone tails. It also interferes with ELG1-dependent DNA repair in HEK293T cells and serves as a delayed death inhibitor of the malarial parasite plastid. Additionally, it displays antimicrobial properties, with varying degrees of activity: it inhibits Klebsiella pneumoniae MDR (15.4%), Pseudomonas aeruginosa (9.81%), Candida albicans (24.9%), Staphylococcus aureus MRSA (3.26%), and Escherichia coli (5.58%). However, it shows negligible or negative inhibition against Cryptococcus neoformans (-0.99%) and Acinetobacter baumannii (-8.45%), suggesting limited or no activity against these strains..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	4-Isopropoxybenzoic acid (AI3 12104) is a Centromere-Associated Protein E inhibitor.
Synonyms	AI3-12104, AI312104, AI3 12104

Chemical Properties

Molecular Weight	180.2
Formula	C₁₀H₁₂O₃
Cas No.	13205-46-4
Smiles	CC(C)OC1=CC=C(C=C1)C(O)=O
Relative Density.	1.13g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (305.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5494 mL	27.7469 mL	55.4939 mL	277.4695 mL
5 mM	1.1099 mL	5.5494 mL	11.0988 mL	55.4939 mL
10 mM	0.5549 mL	2.7747 mL	5.5494 mL	27.7469 mL
20 mM	0.2775 mL	1.3873 mL	2.7747 mL	13.8735 mL
50 mM	0.1110 mL	0.5549 mL	1.1099 mL	5.5494 mL
100 mM	0.0555 mL	0.2775 mL	0.5549 mL	2.7747 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc