A2AR Protein-VLP, Human, Recombinant (Flag)

Name: A2AR Protein-VLP, Human, Recombinant (Flag)
Brand: TargetMol
SKU: TMPY-07100
Rating: 4.5 (1 reviews)

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Catalog No. TMPY-07100 Copy Product Info

A2AR Protein-VLP, Human, Recombinant (Flag) is expressed in HEK293 Cells. The accession number is P29274.

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Pack Size	Price	USA Stock	Global Stock
10 µg	$582	7-10 days	7-10 days
20 µg	$983	7-10 days	7-10 days
50 µg	$1,490	7-10 days	7-10 days
100 µg	$2,380	7-10 days	7-10 days
200 µg	$3,590	7-10 days	7-10 days
500 µg	$8,630	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized A2AR Protein-VLP, Human, Recombinant (Flag) (Cat#TMPY-07100) at 5 μg/mL (100 μL/well) can bind Anti-Human ADORA2A Monoclonal antibody, Mouse IgG2a, the EC50 is 5-20 ng/mL.
Description	A2AR Protein-VLP, Human, Recombinant (Flag) is expressed in HEK293 Cells. The accession number is P29274.
Species	Human
Expression System	HEK293 Cells
Tag	N-Flag
Accession Number	P29274
Construction	A DNA sequence encoding the Human AA2AR (P29274) (Met1-Ser412) was expressed with a flag tag at the N-terminus.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile 50 mM Hepes, 150 mM NaCl, 10% Trehalose, pH 7.2. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Research Background	Adenosine Receptor Subtype A2a (A2aR) is a G-protein coupled receptor that mediates adenosine (a potent immunosuppressor) signaling in leukocytes. A2aR has been implicated in neuroinflammation and synaptic plasticity-related processes. Signaling through A2aRs inhibits local and systemic inflammation and A2aR expression showed protective effects against non-alcoholic steatohepatitis (NASH) in the liver. A2aR deficiency triggers spontaneous inflammation and NASH-Hepatocellular Carcinoma (HCC) in mice while low A2aR gene expression in human HCC is associated with hepatic inflammation and poor survival. Reducing adenosine signaling via A2aR antagonism provides an alternative targeted strategy to modulate the number and efficacy of infiltrating effector T cells within the immunosuppressive tumor microenvironment. Co-blockade of A2aR signaling and CD73 reduced tumor initiation, growth, and metastasis.

Chemical Properties

Molecular Weight

38.06 kDa (predicted)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -70℃ or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.