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Metabolism

Acetyl-CoA Carboxylase

Amino Acids and Derivatives

Angiotensin-converting Enzyme (ACE)

Endogenous Metabolite

Glutathione Peroxidase

(88)

Glyoxalase

(17)

HIF/HIF Prolyl-Hydroxylase

Indoleamine 2,3-Dioxygenase (IDO)

(100)

Isocitrate Dehydrogenase (IDH)

Mitochondrial Metabolism

(240)

N-Acetylglucosaminyltransferase

Procollagen C Proteinase

(1)

Prolyl Endopeptidase (PREP)

Reactive Oxygen Species

Serine/threonin kinase

(94)

Stearoyl-CoA Desaturase (SCD)

Amylase

An amylase is an enzyme that catalyses the hydrolysis of starch (Latin amylum) into sugars. Amylase is present in the saliva of humans and some other mammals, where it begins the chemical process of digestion. The pancreas and salivary gland make amylase (alpha amylase) to hydrolyse dietary starch into disaccharides and trisaccharides which are converted by other enzymes to glucose to supply the body with energy. Plants and some bacteria also produce amylase.

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Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside

pinocembrin-7-o-3-o-galloyl-4-6-hexahydroxydiphenoyl-beta-d-glucoside, Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose

T2S1682205370-59-8

Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside can moderately inhibit α-amylase activity, with an IC50 value of 0.03 µmol/ml.

Amylase

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Cited

α-Amylase

T196159000-90-2

α-Amylase, a hydrolase enzyme, catalyzes the hydrolysis of internal α-1,4-glycosidic linkages in starch, producing glucose and maltose.

Amylase

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Docosapentaenoic acid 22n-3

T1929524880-45-3

Docosapentaenoic acid 22n-3 is present in the cell membranes of all animals and is a component of phospholipids.

Amylase Endogenous Metabolite glycosidase

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Rubusoside

T3S202764849-39-4

1. Rubusoside is a natural sweetener . 2. Rubusoside is a solubilizing agent with antiangiogenic and antiallergic properties.

Amylase NF-κB Others transporter

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Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside

pNP-G7, Ethylidene-4-NP-G7, Ethyliden-4-nitrophenyl-α-D-maltoheptaosid

T7374596597-16-9

Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside (pNP-G7) is a substrate for α-amylase, used to measure α-amylase activity.

Amylase Others

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7,4'-Di-O-methylapigenin

4',7-DIMETHOXY-5-HYDROXYFLAVONE

T56905128-44-9

7,4'-Di-O-methylapigenin (4',7-DIMETHOXY-5-HYDROXYFLAVONE) can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it has hypolipidemic effect on mouse pre-adipocyte (3T3L1) cell lines.

Amylase Endogenous Metabolite

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Amylase

Diastase

T11369000-92-4

Amylase (Diastase) is any one of a group of enzymes which catalyses the breakdown of starch into maltose.

Amylase Others

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Trilobatin

P-Phlorizin

T2S07314192-90-9

Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory response by suppressing the NF-κB signaling pathway.Trilobatin shows a strong inhibitory activity against α-glucosidase and a moderate inhibitory activity against α-amylase for management of postprandial hyperglycemia with less side effect.

Amylase HIV Protease SGLT TNF

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Kaempferol-3,7-di-O-β-glucoside

Kaempferol 3,7-di-O-glucoside

TN436825615-14-9

Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) is a flavonol from Morettia philaena that inhibits α-amylase, α-glucosidase, and acetylcholinesterase. It exhibits neuroprotective activity, slowing amyloid β peptide-induced damage in differentiated neuronal cells SH-SY5Y, and can be used in the study of neurological disorders such as Alzheimer's disease.

Amylase Cholinesterase (ChE)Glucosidase

$176

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Isookanin

TN17881036-49-3

Isookanin shows strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity with the IC50 value of 7.9 ± 0.53 μM. Isookanin is a potent inhibitor of α-amylase (IC50=0.447 mg/ml).

Amylase HSV

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Hemipyocyanine

528-71-2

T20711528-71-2

Hemipyocyanine (528-71-2) is the virulence factor of Gram-negative, aerobic rod bacterium Pseudomonas aeruginosa. Hemipyocyanine is an α-Amylase inhibitor.

Amylase Antibacterial

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Dehydrocholate sodium

Sodium dehydrocholate

T0516145-41-5

Dehydrocholate sodium, a hydrocholeretic, can increase bile output to clear increased bile acid load.

Amylase Autophagy Endogenous Metabolite Lipase Lipid

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Dehydrocholic acid

Sanocholen, Felacrinos, Dehystolin, Decholin

T040881-23-2

Dehydrocholic acid (Dehystolin) is a synthetic bile acid, produced by the oxidation of cholic acid.

Amylase Autophagy Lipase Others

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Bacterial α-Amylase

T761619000-85-5

Bacterial α-Amylase is an enzyme produced by bacteria that catalyzes the hydrolysis reaction of starch into smaller sugar molecules such as maltose and glucose, and can be used to study starch metabolism and enzymatic mechanisms.

Amylase

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α-Amylase-IN-1

T63750148404-10-8

α-Amylase-IN-1 is an α-Amylase inhibitor (IC50: 0.5509 μM). α-Amylase-IN-1 has antioxidant activity with an IC50 value of 53.49 μM for scavenging of DPPH free radicals, and can be used in the study of diabetes and oxidative stress-related diseases.

Amylase Antioxidant

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G3-CNP

G3-CNP, CNPG3, 2Chloro4nitrophenyl αDmaltotrioside, 2-Chloro-4-nitrophenyl a-D-maltotrioside, 2 Chloro 4 nitrophenyl α D maltotrioside

T37834118291-90-0

G3-CNP is a substrate for α-amylase and the hydrolysis product is 2-chloro-4-nitrophenol, which can be used to determine the enzyme activity by colorimetric assay at 405 nm.

Amylase

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Irilone

Irolone, 5,4'-Dihydroxy-6,7-methylenedioxyisoflavone

TN652441653-81-0

Irilone is a flavonoid with α-amylase inhibitory activity and highly selective inhibition of CYP3A4. In addition, Irilone enhances progesterone receptor (PR) signaling via estrogen receptor (ER) and glucocorticoid receptor (GR) when combined with progesterone.Irilone has potential anti-inflammatory activity and inhibits nitric oxide (NO) production by lipopolysaccharide (LPS)-induced RAW264.7 in mouse macrophages.

Amylase Cytochromes P450

$678

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2-Hydroxyquinoline

PDK029159-31-4

Compound PDK0291, with CAS No. 59-31-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0291 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Amylase Glucosidase glycosidase

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Docosapentaenoic acid (22n-3) sodium

Clupanodonic acid sodium

T2062252983837-44-9

Docosapentaenoic acid (22n-3) sodium is a component of phospholipids. It exhibits inhibitory activity against α-amylase and α-glucosidase, with IC50 values of 17 μg/mL and 22 μg/mL, respectively. Additionally, Docosapentaenoic acid 22n-3 sodium enhances cell viability and has mild anti-inflammatory effects.

Amylase glycosidase

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10-14 weeks

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ABCB1-IN-4

T2051961500779-21-4

ABCB1-IN-4 (Compound C6z) is an orally active inhibitor of α-amylase and α-glucosidase, with IC50 values of 1.63 μM and 0.14 μM, respectively. It holds potential for diabetes research.

Amylase

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10-14 weeks

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α-Amylase/α-Glucosidase-IN-19

T206992223505-23-5

α-Amylase/α-Glucosidase-IN-19 (compound 10) is a dual inhibitor of α-amylase and α-glucosidase, with an IC50 of 170.7 μM and 60.37 μM, respectively.

Amylase glycosidase

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10-14 weeks

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E234G HYPE-IN-1

T863141341007-95-1

Compound I2.10 (E234G HYPE-IN-1) functions as an AMPylase inhibitor and exhibits low cytotoxicity toward human cell lines [1].

Amylase

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10-14 weeks

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DPP-4-IN-11

T89089

DPP-4-IN-11 (compound 10) is an orally active DPP-4 inhibitor (IC50=2.75 μM) with anti-type 2 diabetes activity. This compound exerts its hypoglycemic effects by inhibiting the activity of α-glucosidase (IC50=3.02 μM) and α-amylase (IC50=3.3 μM).

Amylase Glucosidase Proteasome

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8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside

T75701925701-05-9

8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside (Compound 3), a natural product isolated from Bidens bipinnata, exhibits 22% inhibition against α-amylase at a concentration of 0.556 mg/mL [1].

Amylase Others

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