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Metabolism

Acetyl-CoA Carboxylase

Amino Acids and Derivatives

Angiotensin-converting Enzyme (ACE)

Endogenous Metabolite

Glutathione Peroxidase

(74)

Glyoxalase

(17)

HIF/HIF Prolyl-Hydroxylase

Indoleamine 2,3-Dioxygenase (IDO)

(98)

Isocitrate Dehydrogenase (IDH)

Mitochondrial Metabolism

(212)

N-Acetylglucosaminyltransferase

Procollagen C Proteinase

(1)

Prolyl Endopeptidase (PREP)

Reactive Oxygen Species

Serine/threonin kinase

(90)

Stearoyl-CoA Desaturase (SCD)

Amylase

An amylase is an enzyme that catalyses the hydrolysis of starch (Latin amylum) into sugars. Amylase is present in the saliva of humans and some other mammals, where it begins the chemical process of digestion. The pancreas and salivary gland make amylase (alpha amylase) to hydrolyse dietary starch into disaccharides and trisaccharides which are converted by other enzymes to glucose to supply the body with energy. Plants and some bacteria also produce amylase.

Filter HomeSignaling PathwaysMetabolismAmylase

Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside

T2S1682205370-59-8

Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside can moderately inhibit α-amylase activity, with an IC50 value of 0.03 µmol/ml.

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Cited

α-Amylase

T196159000-90-2

α-Amylase, a hydrolase enzyme, catalyzes the hydrolysis of internal α-1,4-glycosidic linkages in starch, producing glucose and maltose.

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Rubusoside

T3S202764849-39-4

1. Rubusoside is a natural sweetener . 2. Rubusoside is a solubilizing agent with antiangiogenic and antiallergic properties.

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Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside

T7374596597-16-9

Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside (pNP-G7) is a substrate for α-amylase, used to measure α-amylase activity.

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7,4'-Di-O-methylapigenin

T56905128-44-9

7,4'-Di-O-methylapigenin (4',7-DIMETHOXY-5-HYDROXYFLAVONE) can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it has hypolipidemic effect on mouse pre-adipocyte (3T3L1) cell lines.

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Trilobatin

T2S07314192-90-9

Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory response by suppressing the NF-κB signaling pathway.Trilobatin shows a strong inhibitory activity against α-glucosidase and a moderate inhibitory activity against α-amylase for management of postprandial hyperglycemia with less side effect.

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Kaempferol-3,7-di-O-β-glucoside

TN436825615-14-9

Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) is a flavonol from Morettia philaena that inhibits α-amylase, α-glucosidase, and acetylcholinesterase. It exhibits neuroprotective activity, slowing amyloid β peptide-induced damage in differentiated neuronal cells SH-SY5Y, and can be used in the study of neurological disorders such as Alzheimer's disease.

$176

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Isookanin

TN17881036-49-3

Isookanin shows strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity with the IC50 value of 7.9 ± 0.53 μM. Isookanin is a potent inhibitor of α-amylase (IC50=0.447 mg/ml).

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Hemipyocyanine

T20711528-71-2

Hemipyocyanine (528-71-2) is the virulence factor of Gram-negative, aerobic rod bacterium Pseudomonas aeruginosa. Hemipyocyanine is an α-Amylase inhibitor.

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Bacterial α-Amylase

T761619000-85-5

Bacterial α-Amylase is an enzyme produced by bacteria that catalyzes the hydrolysis reaction of starch into smaller sugar molecules such as maltose and glucose, and can be used to study starch metabolism and enzymatic mechanisms.

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α-Amylase-IN-1

T63750148404-10-8

α-Amylase-IN-1 is an α-Amylase inhibitor (IC50: 0.5509 μM). α-Amylase-IN-1 has antioxidant activity with an IC50 value of 53.49 μM for scavenging of DPPH free radicals, and can be used in the study of diabetes and oxidative stress-related diseases.

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G3-CNP

T37834118291-90-0

G3-CNP is a substrate for α-amylase and the hydrolysis product is 2-chloro-4-nitrophenol, which can be used to determine the enzyme activity by colorimetric assay at 405 nm.

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Irilone

TN652441653-81-0

Irilone is a flavonoid with α-amylase inhibitory activity and highly selective inhibition of CYP3A4. In addition, Irilone enhances progesterone receptor (PR) signaling via estrogen receptor (ER) and glucocorticoid receptor (GR) when combined with progesterone.Irilone has potential anti-inflammatory activity and inhibits nitric oxide (NO) production by lipopolysaccharide (LPS)-induced RAW264.7 in mouse macrophages.

$678

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Docosapentaenoic acid (22n-3) sodium

T2062252983837-44-9

Docosapentaenoic acid (22n-3) sodium is a component of phospholipids. It exhibits inhibitory activity against α-amylase and α-glucosidase, with IC50 values of 17 μg/mL and 22 μg/mL, respectively. Additionally, Docosapentaenoic acid 22n-3 sodium enhances cell viability and has mild anti-inflammatory effects.

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10-14 weeks

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ABCB1-IN-4

T2051961500779-21-4

ABCB1-IN-4 (Compound C6z) is an orally active inhibitor of α-amylase and α-glucosidase, with IC50 values of 1.63 μM and 0.14 μM, respectively. It holds potential for diabetes research.

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10-14 weeks

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α-Amylase/α-Glucosidase-IN-19

T206992223505-23-5

α-Amylase/α-Glucosidase-IN-19 (compound 10) is a dual inhibitor of α-amylase and α-glucosidase, with an IC50 of 170.7 μM and 60.37 μM, respectively.

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10-14 weeks

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Antidiabetic agent 2

T79644

Compound 56 (Antidiabetic agent 2) is a glucose-uptake promoter that inhibits DPP-4, PTP-1B, α-amylase, and α-glucosidase, with IC50 values of 0.036, 0.042, 0.241, and 0.185 μM, respectively. This agent effectively decreases blood glucose levels [1].

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α-Amylase/α-Glucosidase-IN-4

T79402

α-Amylase α-Glucosidase-IN-4 (compound 5), a dual inhibitor targeting α-amylase (Amylases) and α-glucosidase (Glucosidase), exhibits potent inhibition with IC50 values of 1.10 μM and 0.15 μM respectively, and is noted for its potential antidiabetic activity [1].

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E234G HYPE-IN-1

T863141341007-95-1

Compound I2.10 (E234G HYPE-IN-1) functions as an AMPylase inhibitor and exhibits low cytotoxicity toward human cell lines [1].

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10-14 weeks

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α-Amylase/α-Glucosidase-IN-6

T80715

α-Amylase α-Glucosidase-IN-6 (compound 5j) is a potent dual inhibitor of α-amylase and α-glucosidase, with IC50 values of 17.0 µM and 40.1 µM, respectively, and demonstrates anti-hyperglycemic activities [1].

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8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside

T75701925701-05-9

8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside (Compound 3), a natural product isolated from Bidens bipinnata, exhibits 22% inhibition against α-amylase at a concentration of 0.556 mg mL [1].

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DPP-4-IN-11

T89089

DPP-4-IN-11 (compound 10) is an orally active DPP-4 inhibitor (IC50=2.75 μM) with anti-type 2 diabetes activity. This compound exerts its hypoglycemic effects by inhibiting the activity of α-glucosidase (IC50=3.02 μM) and α-amylase (IC50=3.3 μM).

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(+)-Secoisolariciresinol

TN7293145265-02-7

(+)-Secoisolariciresinol is a natural lignan exhibiting inhibitory activity against α-amylase (IC50=9.5 μM). (+)-Secoisolariciresinol is the enantiomer of (-)-Secoisolariciresinol and may be employed in biochemical experiments and drug synthesis research.

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α-Amylase-IN-11

T205363

α-Amylase-IN-11 (compound C5f) is an α-amylase inhibitor with an IC50 of 0.56 μM, effective in reducing glucose levels in vivo. Additionally, it exhibits moderate inhibitory activity against α-glucosidase with an IC50 of 11.03 μM. In mouse models, α-Amylase-IN-11 significantly decreases glucose concentrations, indicating its potential for diabetes research.

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