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Anti-CD204 Monoclonal Antibody (4M704)
(Synonyms: SR-AIII, SR-AII, SR-AI, SR-A, SRA, SCARA1, phSR2, phSR1, MSR1) Copy Product Info
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Synonyms: SR-AIII, SR-AII, SR-AI, SR-A, SRA, SCARA1, phSR2, phSR1, MSR1
Catalog No. TMAT-0319 Copy Product Info
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Anti-CD204 Monoclonal Antibody (4M704) is a Mouse antibody targeting CD204. Anti-CD204 Monoclonal Antibody (4M704) can be used in WB,FCM.
Anti-CD204 Monoclonal Antibody
(4M704)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Stability & Storage
| Description | Anti-CD204 Monoclonal Antibody (4M704) is a Mouse antibody targeting CD204. Anti-CD204 Monoclonal Antibody (4M704) can be used in WB,FCM. |
| Synonyms | SR-AIII, SR-AII, SR-AI, SR-A, SRA, SCARA1, phSR2, phSR1, MSR1 |
| Ig Type | IgG1 |
| Clone | 4M704 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/ml |
| Research Background | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human CD204 (AA: extra 275-451) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | MSR1 |
| Gene ID | |
| Protein Name | Macrophage scavenger receptor types I and II |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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