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AKBA (Synonyms: Acetyl-11-keto-β-boswellic acid, 3-O-Acetyl-11-keto-β-boswellic acid, 3-O-Acetyl-11-keto-beta-...)

Name: AKBA
Brand: TargetMol
SKU: T5S1569
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T5S1569 Copy Product Info

Purity: 99.75%

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AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.

AKBA

Copy Product Info

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Catalog No. T5S1569

Synonyms Acetyl-11-keto-β-boswellic acid, 3-O-Acetyl-11-keto-β-boswellic acid, 3-O-Acetyl-11-keto-beta-boswellic acid

AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.

Cas No. 67416-61-9

Pack Size	Price	USA Stock	Global Stock
1 mg	$32	In Stock	In Stock
5 mg	$73	In Stock	In Stock
10 mg	$107	In Stock	In Stock
25 mg	$177	In Stock	In Stock
50 mg	$263	In Stock	In Stock
100 mg	$418	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$83	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.75%

Color:White

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COA LCMS HNMR

Product Introduction

AKBA AI Summary

AKBA is a multifaceted bioactive compound exhibiting a range of pharmacological activities. It demonstrates cytotoxicity against various human cancer cell lines, including MCF7, DU145, SW620, 502713, HT29, HL60, HeLa, A253, DLD1, A2780, HCT8, and FR2 cells, with varying inhibition percentages and IC50 values, showing potent anticancer potential. Additionally, AKBA inhibits the prolyl endopeptidase enzyme with an IC50 of 7890 nM and shows significant inhibition against 11beta-HSD1 and 11beta-HSD2 enzymes involved in cortisone metabolism. The compound also demonstrates notable anti-inflammatory properties by inhibiting LPS-induced NO production in mouse RAW264.7 cells and suppressing the expression of TNFalpha and IL-6 in both mouse and human PBMCs. Furthermore, it effectively inhibits lipoxygenase 5 and microsomal PGES1, suggesting potential anti-inflammatory applications. In terms of antiviral activity, AKBA shows moderate inhibition of SARS-CoV-2 3CL-Pro protease and partial inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells. Additionally, the compound exhibits moderate solubility and permeability characteristics, with enhanced plasma concentration and brain uptake when formulated with Lipoid S100 and pluronic f127. Moreover, it inhibits VEGFR-2 by 40% at 50 µM and has noteworthy antiproliferative activity against HUVEC cells. The compound also inhibits key enzymes involved in inflammation and cancer pathways, including human recombinant 5-lipoxygenase, but shows limited activity against COX enzymes and HDAC6. Collectively, AKBA is a diverse bioactive entity with promising anticancer, anti-inflammatory, and antiviral properties, reflecting its potential as a therapeutic candidate across multiple disease models..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.
Synonyms	Acetyl-11-keto-β-boswellic acid, 3-O-Acetyl-11-keto-β-boswellic acid, 3-O-Acetyl-11-keto-beta-boswellic acid

Chemical Properties

Molecular Weight	512.72
Formula	C₃₂H₄₈O₅
Cas No.	67416-61-9
Smiles	CC1CCC2(C)CCC3(C)C(=CC(=O)C4C5(C)CCC(OC(C)=O)C(C)(C5CCC34C)C(O)=O)C2C1C
Relative Density.	1.13 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 13.89 mg/mL (27.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9504 mL	9.7519 mL	19.5038 mL	97.5191 mL
5 mM	0.3901 mL	1.9504 mL	3.9008 mL	19.5038 mL
10 mM	0.1950 mL	0.9752 mL	1.9504 mL	9.7519 mL
20 mM	0.0975 mL	0.4876 mL	0.9752 mL	4.8760 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc