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Neostigmine bromide

Name: Neostigmine bromide
Brand: TargetMol
SKU: T1624
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1624Cas No. 114-80-7

Alias Neoserine bromide, Eustigmin bromide

Neostigmine bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.

Neostigmine bromide

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Purity: 98.39%

Catalog No. T1624Alias Neoserine bromide, Eustigmin bromideCas No. 114-80-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$33	-	In Stock
1 mL x 10 mM (in DMSO)	$53	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.39%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Neostigmine bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
Synonyms	Neoserine bromide, Eustigmin bromide

Chemical Properties

Molecular Weight	303.2
Formula	C₁₂H₁₉BrN₂O₂
Cas No.	114-80-7
Smiles	[Br-].CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C
Relative Density.	1.4344 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 38 mg/mL (125.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2982 mL	16.4908 mL	32.9815 mL	164.9077 mL
5 mM	0.6596 mL	3.2982 mL	6.5963 mL	32.9815 mL
10 mM	0.3298 mL	1.6491 mL	3.2982 mL	16.4908 mL
20 mM	0.1649 mL	0.8245 mL	1.6491 mL	8.2454 mL
50 mM	0.0660 mL	0.3298 mL	0.6596 mL	3.2982 mL
100 mM	0.0330 mL	0.1649 mL	0.3298 mL	1.6491 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc