Shopping Cart

Your shopping cart is currently empty

AVE5688

Name: AVE5688
Brand: TargetMol
SKU: T10421
Price: 148 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T10421Cas No. 613260-13-2

AVE5688, an inhibitor of glycogen phosphorylase (GP), has IC50 values of 430 nM and 915 nM, and Kd values of 170 nM and 530 nM for rmGPb and rmGPa, respectively. It is suitable for research on type 2 diabetes.

AVE5688

😃Good

Purity: 99.65%

Catalog No. T10421Cas No. 613260-13-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$148	In Stock	In Stock
5 mg	$263	In Stock	In Stock
10 mg	$373	In Stock	In Stock
25 mg	$562	In Stock	In Stock
50 mg	$738	In Stock	In Stock
100 mg	$1,010	In Stock	In Stock
200 mg	$1,360	-	In Stock
1 mL x 10 mM (in DMSO)	$295	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.65%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	AVE5688, an inhibitor of glycogen phosphorylase (GP), has IC50 values of 430 nM and 915 nM, and Kd values of 170 nM and 530 nM for rmGPb and rmGPa, respectively. It is suitable for research on type 2 diabetes.
Targets&IC50	GPb (rabbit muscle):430 nM , GPa (rabbit muscle):530 nM , GPa (rabbit muscle):915 nM , GPb (rabbit muscle):(kd)170 nM

Chemical Properties

Molecular Weight	438.69
Formula	C₁₆H₈ClF₅N₂O₅
Cas No.	613260-13-2
Smiles	O(C(F)(F)F)C1=C(NC(NC(=O)C2=C(Cl)C=C(F)C(F)=C2)=O)C=CC(C(O)=O)=C1
Relative Density.	1.661 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (125.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.7 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2795 mL	11.3976 mL	22.7951 mL	113.9757 mL
5 mM	0.4559 mL	2.2795 mL	4.5590 mL	22.7951 mL
10 mM	0.2280 mL	1.1398 mL	2.2795 mL	11.3976 mL
20 mM	0.1140 mL	0.5699 mL	1.1398 mL	5.6988 mL
50 mM	0.0456 mL	0.2280 mL	0.4559 mL	2.2795 mL
100 mM	0.0228 mL	0.1140 mL	0.2280 mL	1.1398 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc