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OD36 hydrochloride

Catalog No. T61424 CAS 2387510-88-3

Synonyms: OD 36 hydrochloride, OD-36 hydrochloride

OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of the ALK2 kinase and effectively antagonizes mutant ALK2 signaling and osteogenic differentiation.OD36 hydrochloride targets ALK2. OD36 hydrochloride targets ALK2 with a KD of 37 nM.

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OD36 hydrochloride, CAS 2387510-88-3

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,290.00
50 mg	6-8 weeks	$ 1,680.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Purity: 99.85%

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Description	OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of the ALK2 kinase and effectively antagonizes mutant ALK2 signaling and osteogenic differentiation.OD36 hydrochloride targets ALK2. OD36 hydrochloride targets ALK2 with a KD of 37 nM.
In vitro	OD36 hydrochloride inhibits ALK2 (IC50=47 nM) and ALK2 R206H （IC50=22 nM.[1] OD36 hydrochloride exhibits a KD of 90 nM, demonstrating significant activity against ALK1. Additionally, it effectively acts as an antagonist against mutant ALK2 signaling and inhibits osteogenic differentiation.[2] OD36 hydrochloride (0.1-1 μM; 24 h) effectively hinders the BMP-6 (50 ng/mL)-induced phosphorylation of Smad1/5 in KS483 cells. Moreover, when fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs) are preincubated with 0.5 μM OD36 hydrochloride, it completely blocks the activation of Smad1/5 as well as the expression of the target genes ID-1 and ID-3 in response to activin A.[2]
In vivo	OD36 (6.25 mg/kg; i.p.; once; C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis) inhibited the recruitment of inflammatory cells to the peritoneum, specifically that of neutrophils, and, to a lesser extent, lymphocytes. Decreased RIPK2-specific genes as well as inflammatory cytokine and chemokine gene expression. It alleviates inflammation in an acute peritonitis mice model.[3]

Synonyms	OD 36 hydrochloride, OD-36 hydrochloride
Molecular Weight	367.23
Formula	C16H16Cl2N4O2
CAS No.	2387510-88-3

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Tigno-Aranjuez JT, et al. In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J Biol Chem. 2014 Oct 24;289(43):29651-64. 2. Sánchez-Duffhues G, et al. Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells. JBMR Plus. 2019 Oct 7;3(11):e10230. 3. Tigno-Aranjuez JT, et al. In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J Biol Chem. 2014 Oct 24;289(43):29651-64.

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Keywords

OD36 hydrochloride 2387510-88-3 Angiogenesis Apoptosis NF-Κb Tyrosine Kinase/Adaptors ALK RIP kinase OD 36 Hydrochloride OD36 Hydrochloride OD-36 Hydrochloride OD 36 hydrochloride OD-36 hydrochloride inhibitor inhibit

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