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IL-11R alpha/IL-11RA Protein, Human, Recombinant (His)

Catalog No. TMPY-01462
Synonyms: interleukin 11 receptor subunit alpha, hCG_2011440, CRSDA, interleukin 11 receptor subunit α, IL11RA, MGC2146

IL-11R alpha/IL-11RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.6 kDa and the accession number is Q14626-1.

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IL-11R alpha/IL-11RA Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
100 μg In stock $ 386.00
200 μg 5 days $ 682.00
500 μg 5 days $ 1,440.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information Loaded Human IL11RA Protein, His Tag on His1K Biosensor, can bind Human IL11 protein with an affinity constant of 0.353nM as determined in BLI assay (Routinely tested).
Description IL-11R alpha/IL-11RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.6 kDa and the accession number is Q14626-1.
Species Human
Expression System HEK293 Cells
Tag C-His
Accession Number Q14626-1
Synonyms interleukin 11 receptor subunit alpha, hCG_2011440, CRSDA, interleukin 11 receptor subunit α, IL11RA, MGC2146
Construction The extracellular domain of Human IL11Rα (NP_004503.1) (Met 1-Val 363) was expressed, with a fused polyhistidine tag at the C-terminus.
Protein Purity ≥ 97 % as determined by SDS-PAGE ≥ 95 % as determined by SEC-HPLC.

Molecular Weight 38.6 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. This particular receptor is very similar to the ciliary neurotrophic factor since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified. IL11RA/IL-11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11, and CT1 can utilize IL6ST for initiating signal transmission. Defects in IL11RA/IL-11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly.

References and Literature

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Keywords

IL-11R alpha/IL-11RA Protein, Human, Recombinant (His) interleukin 11 receptor subunit alpha MGC-2146 hCG_2011440 CRSDA interleukin 11 receptor subunit α IL11RA MGC2146 MGC 2146 recombinant recombinant-proteins proteins protein

 

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