Anti-ALOX5 Antibody (7O959)

Name: Anti-ALOX5 Antibody (7O959)
Brand: TargetMol
SKU: TMAH-00055
Rating: 4.5 (1 reviews)

(Synonyms: LOG5, EC 1.13.11.34, Arachidonate 5-lipoxygenase, ALOX 5, 5-LO, 5-lipoxygenase) Copy Product Info

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Synonyms: LOG5, EC 1.13.11.34, Arachidonate 5-lipoxygenase, ALOX 5, 5-LO, 5-lipoxygenase

Catalog No. TMAH-00055 Copy Product Info

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Anti-ALOX5 Antibody (7O959) is an antibody targeting ALOX5. Anti-ALOX5 Antibody (7O959) can be used in ELISA,IHC.

Anti-ALOX5 Antibody
(7O959)

Pack Size	Price	USA Stock	Global Stock	Quantity
50 μL	$209	7-10 days	7-10 days
100 μL	$349	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-ALOX5 Antibody (7O959) is an antibody targeting ALOX5. Anti-ALOX5 Antibody (7O959) can be used in ELISA,IHC.
Synonyms	LOG5, EC 1.13.11.34, Arachidonate 5-lipoxygenase, ALOX 5, 5-LO, 5-lipoxygenase
Ig Type	Rabbit IgG
Clone	7O959
Reactivity	Human

Application	ELISA IHC
Recommended Dose	IHC:1:50-1:200.
Antibody Type	Monoclonal
Subcellular Localization	Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Cytoplasm, perinuclear region. Cytoplasm, cytosol. Nucleus envelope. Nucleus intermembrane space.
Construction	Recombinant Antibody
Purification	Affinity-chromatography
Appearance	Liquid
Formulation	Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research Background	Catalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation. Also catalyzes the oxygenation of arachidonate into 8-hydroperoxyicosatetraenoate (8-HPETE) and 12-hydroperoxyicosatetraenoate (12-HPETE). Displays lipoxin synthase activity being able to convert (15S)-HETE into a conjugate tetraene. Although arachidonate is the preferred substrate, this enzyme can also metabolize oxidized fatty acids derived from arachidonate such as (15S)-HETE, eicosapentaenoate (EPA) such as (18R)- and (18S)-HEPE or docosahexaenoate (DHA) which lead to the formation of specialized pro-resolving mediators (SPM) lipoxin and resolvins E and D respectively, therefore it participates in anti-inflammatory responses. Oxidation of DHA directly inhibits endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator-activated receptor gamma (PPARgamma). It does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers. In addition to inflammatory processes, it participates in dendritic cell migration, wound healing through an antioxidant mechanism based on heme oxygenase-1 (HO-1) regulation expression, monocyte adhesion to the endothelium via ITGAM expression on monocytes. Moreover, it helps establish an adaptive humoral immunity by regulating primary resting B cells and follicular helper T cells and participates in the CD40-induced production of reactive oxygen species (ROS) after CD40 ligation in B cells through interaction with PIK3R1 that bridges ALOX5 with CD40. Also may play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK. Can regulate bone mineralization and fat cell differentiation increases in induced pluripotent stem cells.

Related Conjugates and Formulations

Conjucates

Unconjugated

Antigen Details

Immunogen	A synthetic peptide: Human 5 Lipoxygenase
Antigen Species	Human
Gene Name	ALOX5
Gene ID	240
Uniprot ID	P09917
Biology Area	Cancer, Cardiovascular, Metabolism, Signal transduction