Popular Searches
Diphenyleneiodonium chlorideEpacadostatGilteritinibDinaciclibRo-3306
TargetMol | Star Product
Wikimole
TargetMol | New Product
New Product
TargetMol | Compound Library
Compound Library
Contact UsQuotation
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPRelated productsBioactivityChemical infoStorage&SolubilityCalculator

5-HT2B antagonist-1

🥰Excellent
Catalog No. T9842Cas No. 393129-91-4

5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 of 33.4 nM, suitable for studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease, or gastrointestinal disease [1] [2].

5-HT2B antagonist-1

5-HT2B antagonist-1

🥰Excellent
Purity: 99.965%
Catalog No. T9842Cas No. 393129-91-4
5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 of 33.4 nM, suitable for studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease, or gastrointestinal disease [1] [2].
Pack SizePriceAvailabilityQuantity
10 mg$38In Stock
25 mg$68In Stock
50 mg$120In Stock
100 mg$200In Stock
500 mg$493In Stock
1 mL x 10 mM (in DMSO)$29In Stock
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View More

Batch Information

Select Batch
Purity:99.965%
Contact us for more batch information

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity
Description
5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 of 33.4 nM, suitable for studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease, or gastrointestinal disease [1] [2].
Targets&IC50
5-HT2B receptor:33.4 nM
In vitro
5-HT2B antagonist-1 (compound 5g) exhibits sodium channel binding activity with IC50 values ranging from 12.6 to 57.5 μM [1] and inhibits 5-HT2B receptor activity by less than 50% at 1 μM in CHO-K1 cell lines (compound 1-e) [3].
In vivo
The oral administration of 5-HT2B antagonist-1 (compound 15) at a dosage of 30 mg/kg significantly reduces visceral hypersensitivity in irritable bowel syndrome (IBS) rats [2].
Chemical Properties
Molecular Weight296.17
FormulaC11H14BrN5
Cas No.393129-91-4
SmilesCC1(C)NC(Nc2ccc(Br)cc2)=NC(N)=N1
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

WAY388264A5-HT2B antagonist-1WAY 388264 A
Related Tags: buy 5-HT2B antagonist-1 | purchase 5-HT2B antagonist-1 | 5-HT2B antagonist-1 cost | order 5-HT2B antagonist-1 | 5-HT2B antagonist-1 chemical structure | 5-HT2B antagonist-1 in vivo | 5-HT2B antagonist-1 in vitro | 5-HT2B antagonist-1 formula | 5-HT2B antagonist-1 molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.