Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC 50 of 33.4 nM. It can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease [1] [2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 328.00 | |
100 mg | In stock | $ 537.00 | |
500 mg | In stock | $ 1,150.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 70.00 |
Description | 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC 50 of 33.4 nM. It can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease [1] [2]. |
In vitro | 5-HT2B antagonist-1 (compound 5g) demonstrates sodium channel binding activity, exhibiting IC50 values between 12.6 to 57.5 μM [1]. Additionally, it (compound 1-e) inhibits 5-HT2B receptor activity by less than 50% at a concentration of 1 μM in CHO-K1 cell lines [3]. |
In vivo | 5-HT2B antagonist-1 (compound 15) (oral gavage, 30 mg/kg) significantly reduces visceral hypersensitivity in irritable bowel syndrome (IBS) rats [2]. |
Molecular Weight | 296.17 |
Formula | C11H14BrN5 |
CAS No. | 393129-91-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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5-HT2B antagonist-1 393129-91-4 WAY388264A WAY 388264 A inhibitor inhibit