Anti-CD31 Antibody (2K688)

Name: Anti-CD31 Antibody (2K688)
Brand: TargetMol
SKU: TMAB-00354
Rating: 4.5 (1 reviews)

(Synonyms: PECAM-1, PECA1, GPIIA', FLJ58394, FLJ34100, EndoCAM, CD31) Copy Product Info

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Synonyms: PECAM-1, PECA1, GPIIA', FLJ58394, FLJ34100, EndoCAM, CD31

Catalog No. TMAB-00354 Copy Product Info

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Anti-CD31 Antibody (2K688) is a Mouse antibody targeting CD31. Anti-CD31 Antibody (2K688) can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB.

Pack Size	Price	USA Stock	Global Stock
50 μL	$220	7-10 days	7-10 days
100 μL	$372	7-10 days	7-10 days
200 μL	$529	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-CD31 Antibody (2K688) is a Mouse antibody targeting CD31. Anti-CD31 Antibody (2K688) can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB.
Synonyms	PECAM-1, PECA1, GPIIA', FLJ58394, FLJ34100, EndoCAM, CD31
Ig Type	IgG1
Clone	2K688
Reactivity	Human

Application	FCM ICC/IF IF IHC-Fr IHC-P WB
Recommended Dose	FCM=1 μg/Test; ICC/IF=1:200-800; IF=1:200-2000; IHC-Fr=1:200-2000; IHC-P=1:200-2000; WB=1:1000-10000
Antibody Type	Monoclonal
Host Species	Mouse
Subcellular Localization	Isoform Long: Membrane; Single-pass type I membrane protein. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.Isoform Delta15: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Tissue Specificity	Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369).Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:19342684, PubMed:175803
Construction	Hybridoma Monoclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]

Antigen Details

Immunogen	Recombinant Protein: human CD31 28-601/727aa (C-6x His-Tag)
Antigen Species	Human
Gene Name	PECAM1
Gene ID	5175
Protein Name	Platelet endothelial cell adhesion molecule
Uniprot ID	P16284
Function	Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308).Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684).Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302).Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308).Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892).Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892).Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896).Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896).Induces susceptibility to atherosclerosis (By similarity).