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1588-A4

Name: 1588-A4
Brand: TargetMol
SKU: T22249
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22249Cas No. 1698027-20-1

Alias ARS-1620 Intermediate

1588-A4 (ARS-1620 Intermediate) is an intermediate of ARS-1620 which is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.

1588-A4

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Purity: 98.59%

Catalog No. T22249Alias ARS-1620 IntermediateCas No. 1698027-20-1

1588-A4 (ARS-1620 Intermediate) is an intermediate of ARS-1620 which is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$53	In Stock	In Stock
5 mg	$112	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$272	In Stock	In Stock
50 mg	$389	In Stock	In Stock
100 mg	$529	In Stock	In Stock
200 mg	$691	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.59%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	1588-A4 (ARS-1620 Intermediate) is an intermediate of ARS-1620 which is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
Synonyms	ARS-1620 Intermediate

Chemical Properties

Molecular Weight	445.71
Formula	C₁₇H₁₉BrClFN₄O₂
Cas No.	1698027-20-1
Smiles	FC=1C2=C(C(=NC=N2)N3CCN(C(OC(C)(C)C)=O)CC3)C=C(Cl)C1Br
Relative Density.	1.521 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 6.67 mg/mL (14.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2436 mL	11.2181 mL	22.4361 mL	112.1806 mL
5 mM	0.4487 mL	2.2436 mL	4.4872 mL	22.4361 mL
10 mM	0.2244 mL	1.1218 mL	2.2436 mL	11.2181 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc