Powder: -20°C for 3 years | In solvent: -80°C for 1 year
20S Proteasome activator 1 is a 20S proteasome activator with IC50 of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites and 1.8 μM for caspase sites. 20S Proteasome activator 1 prevents the accumulation of pathogenic alpha-synuclein A53T mutants through translation in the cellular system, thereby reducing the probability of disease occurrence. The 20S Proteasome activator 1 can be used to study neurodegenerative diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 98.00 | |
25 mg | In stock | $ 192.00 | |
50 mg | In stock | $ 328.00 | |
100 mg | In stock | $ 538.00 |
Description | 20S Proteasome activator 1 is a 20S proteasome activator with IC50 of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites and 1.8 μM for caspase sites. 20S Proteasome activator 1 prevents the accumulation of pathogenic alpha-synuclein A53T mutants through translation in the cellular system, thereby reducing the probability of disease occurrence. The 20S Proteasome activator 1 can be used to study neurodegenerative diseases. |
Targets&IC50 | Caspase-like site:1.8 μM, Trypsin like site:0.3 μM, Chymotrypsin-like site:0.7 μM |
In vitro |
At concentrations of 2.5-15 μM and a treatment duration of 45 minutes, 20S Proteasome activator 1 (compound 19) degrades 73% of α-synuclein at 10 μM and over 80% at 15 μM.[1] At concentrations of 5-15 μM and a 24-hour treatment period, 20S Proteasome activator 1 reduces A53T mutant α-synuclein by 25%. It also exhibits a dose-dependent reduction in the augmentation of α-synuclein in Hek-293T cells transiently transfected with an A53T mutant α-synuclein plasmid, achieving a 67% decrease at 15 μM.[1] |
Molecular Weight | 492.97 |
Formula | C27H19ClF2N2OS |
CAS No. | 2761578-18-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 49.30 mg/mL (100 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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20S Proteasome activator 1 2761578-18-9 Proteases/Proteasome Ubiquitination Proteasome inhibitor inhibit