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20S Proteasome activator 1

Name: 20S Proteasome activator 1
Brand: TargetMol
SKU: T63321
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63321Cas No. 2761578-18-9

20S Proteasome activator 1 is a 20S proteasome activator with IC50 values of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites, and 1.8 μM for caspase sites. It prevents the accumulation of pathogenic alpha-synuclein (A53T) mutants through translation in the cellular system, thereby reducing the probability of disease occurrence. 20S Proteasome activator 1 can be used to study neurodegenerative diseases.

20S Proteasome activator 1

🥰Excellent

Purity: 99.82%

Catalog No. T63321Cas No. 2761578-18-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$64	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$192	In Stock	In Stock
50 mg	$328	In Stock	In Stock
100 mg	$538	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	20S Proteasome activator 1 is a 20S proteasome activator with IC50 values of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites, and 1.8 μM for caspase sites. It prevents the accumulation of pathogenic alpha-synuclein (A53T) mutants through translation in the cellular system, thereby reducing the probability of disease occurrence. 20S Proteasome activator 1 can be used to study neurodegenerative diseases.
Targets&IC50	Chymotrypsin-like site:0.7 μM, Caspase-like site:1.8 μM, Trypsin like site:0.3 μM
In vitro	At concentrations of 2.5-15 μM and a treatment duration of 45 minutes, 20S Proteasome activator 1 (compound 19) degrades 73% of α-synuclein at 10 μM and over 80% at 15 μM.[1] At concentrations of 5-15 μM and a 24-hour treatment period, 20S Proteasome activator 1 reduces A53T mutant α-synuclein by 25%. It also exhibits a dose-dependent reduction in the augmentation of α-synuclein in Hek-293T cells transiently transfected with an A53T mutant α-synuclein plasmid, achieving a 67% decrease at 15 μM.[1]

Chemical Properties

Molecular Weight	492.97
Formula	C₂₇H₁₉ClF₂N₂OS
Cas No.	2761578-18-9
Smiles	C(CC(N(C1=CC=C(F)C=C1)C2=CC=C(F)C=C2)=O)N3C=4C(SC=5C3=CC=CC5)=CC=C(Cl)C4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (101.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.07 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0285 mL	10.1426 mL	20.2852 mL	101.4261 mL
5 mM	0.4057 mL	2.0285 mL	4.0570 mL	20.2852 mL
10 mM	0.2029 mL	1.0143 mL	2.0285 mL	10.1426 mL
20 mM	0.1014 mL	0.5071 mL	1.0143 mL	5.0713 mL
50 mM	0.0406 mL	0.2029 mL	0.4057 mL	2.0285 mL
100 mM	0.0203 mL	0.1014 mL	0.2029 mL	1.0143 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc