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20S Proteasome activator 1

Name: 20S Proteasome activator 1
Brand: TargetMol
SKU: T63321
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63321Cas No. 2761578-18-9

20S Proteasome activator 1 is a 20S proteasome activator with IC50 values of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites, and 1.8 μM for caspase sites. It prevents the accumulation of pathogenic alpha-synuclein (A53T) mutants through translation in the cellular system, thereby reducing the probability of disease occurrence. 20S Proteasome activator 1 can be used to study neurodegenerative diseases.

20S Proteasome activator 1

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Purity: 99.82%

Catalog No. T63321Cas No. 2761578-18-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$64	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$192	In Stock	In Stock
50 mg	$328	In Stock	In Stock
100 mg	$538	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	20S Proteasome activator 1 is a 20S proteasome activator with IC50 values of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites, and 1.8 μM for caspase sites. It prevents the accumulation of pathogenic alpha-synuclein (A53T) mutants through translation in the cellular system, thereby reducing the probability of disease occurrence. 20S Proteasome activator 1 can be used to study neurodegenerative diseases.
Targets&IC50	Trypsin like site:0.3 μM, Chymotrypsin-like site:0.7 μM, Caspase-like site:1.8 μM
In vitro	At concentrations of 2.5-15 μM and a treatment duration of 45 minutes, 20S Proteasome activator 1 (compound 19) degrades 73% of α-synuclein at 10 μM and over 80% at 15 μM.[1] At concentrations of 5-15 μM and a 24-hour treatment period, 20S Proteasome activator 1 reduces A53T mutant α-synuclein by 25%. It also exhibits a dose-dependent reduction in the augmentation of α-synuclein in Hek-293T cells transiently transfected with an A53T mutant α-synuclein plasmid, achieving a 67% decrease at 15 μM.[1]

Chemical Properties

Molecular Weight	492.97
Formula	C₂₇H₁₉ClF₂N₂OS
Cas No.	2761578-18-9
Smiles	C(CC(N(C1=CC=C(F)C=C1)C2=CC=C(F)C=C2)=O)N3C=4C(SC=5C3=CC=CC5)=CC=C(Cl)C4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (507.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0285 mL	10.1426 mL	20.2852 mL	101.4261 mL
5 mM	0.4057 mL	2.0285 mL	4.0570 mL	20.2852 mL
10 mM	0.2029 mL	1.0143 mL	2.0285 mL	10.1426 mL
20 mM	0.1014 mL	0.5071 mL	1.0143 mL	5.0713 mL
50 mM	0.0406 mL	0.2029 mL	0.4057 mL	2.0285 mL
100 mM	0.0203 mL	0.1014 mL	0.2029 mL	1.0143 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc