store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 117.00 | |
2 mg | In stock | $ 169.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 463.00 | |
25 mg | In stock | $ 818.00 | |
50 mg | In stock | $ 1,170.00 | |
100 mg | In stock | $ 1,560.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 363.00 |
Description | AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies. |
In vitro | AZD-9574 inhibits PARP1 with IC50s range between 0.3-2 nM in all tested cell lines which is >8000-fold selectivity compared to PARP2, PARP3, PARP5a and PARP6[1]. |
In vivo | In an intracranial xenograft mice model of breast cancer brain metastases, AZD-9574 (3 mg/kg) shows sustained tumour growth suppression and results in a significantly extended survival of mice[1]. |
Molecular Weight | 428.44 |
Formula | C21H22F2N6O2 |
CAS No. | 2756333-39-6 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 8 mg/mL (18.67 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AZD-9574 2756333-39-6 Chromatin/Epigenetic DNA Damage/DNA Repair PARP PPAR Peroxisome proliferator-activated receptors breast cancer inhibit HRR HRR-deficient cells homologous recombination repair AZD 9574 HRD+ AZD9574 Advanced Solid Malignancy Inhibitor aberrant DNA repair inhibitor