Shopping Cart

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

ROS

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen. Examples include peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen. The reduction of molecular oxygen (O2) produces superoxide (•O−2), which is the precursor of most other reactive oxygen species.In a biological context, ROS are formed as a natural byproduct of the normal metabolism of oxygen and have important roles in cell signaling and homeostasis. However, during times of environmental stress (e.g., UV or heat exposure), ROS levels can increase dramatically.

Filter HomeSignaling PathwaysImmunology/InflammationROS

Deferoxamine

Desferrioxamine B, Deferoxamine B

T12435870-51-9

Deferoxamine (Desferrioxamine B) is an iron chelator. Deferoxamine can be used to reduce the accumulation and deposition of iron in tissues. Deferoxamine can improve neurological dysfunction by inhibiting ferroptosis and neuroinflammation after traumatic brain injury. It has antioxidant, anti-proliferation and anti-tumor activities, and can induce the production of HIF-1α, apoptosis and autophagy in cancer cells. It can be used to treat acute iron toxicity and COVID-19 related diseases.

Akt Antioxidant Apoptosis Autophagy HIF HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species ROS

In Stock

Size

QTY

Cited

Deferoxamine Mesylate

DFOM, Desferrioxamine B mesylate

T1637138-14-7

Deferoxamine Mesylate (DFOM) is an iron chelator and ferroptosis inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF-1α levels and induces apoptosis.

Akt Apoptosis Autophagy Beta Amyloid Ferroptosis HIF/HIF Prolyl-Hydroxylase Mitophagy Reactive Oxygen Species ROS

In Stock

Size

QTY

Cited

Lorlatinib

PF-6463922, PF-06463922, Loratinib

T30611454846-35-5

Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity.

ALK Apoptosis ROS ROS Kinase Tyrosine Kinases

In Stock

Size

QTY

Cited

FX-11

LDHA Inhibitor FX11

T15362213971-34-7

FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor activity during xenotransplantation of lymphoma and pancreatic cancer.

Apoptosis Dehydrogenase Reactive Oxygen Species ROS

In Stock

Size

QTY

Acetylcysteine

N-Acetyl-L-cysteine, N-Acetylcysteine, N-Acetyl Cysteine, NAC, LNAC

T0875616-91-1

Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus thickness, and has anti-influenza viral activity.

Apoptosis Endogenous Metabolite Ferroptosis Influenza Virus Reactive Oxygen Species ROS TNF

In Stock

Size

QTY

Cited

Pyridinium bisretinoid A2E

A2E

T74051173449-96-2

Pyridinium bisretinoid A2E (A2E) is a fluorescent chromophore isolated from lipofuscin in retinal pigment epithelium, a lipophilic cation and weak photosensitizer with cytotoxicity. A2E promotes apoptosis under blue light exposure and induces autophagy under photoactivation, damaging membrane integrity in a concentration-dependent manner.

Apoptosis Autophagy Photosensitizer Reactive Oxygen Species ROS

$829

In Stock

Size

QTY

Quercetin

Sophoretin

T2174117-39-5

Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90.

Apoptosis Autophagy Mitophagy PI3K Reactive Oxygen Species ROS

In Stock

Size

QTY

Cited

L 012 sodium salt

T22096143556-24-5

L 012 sodium salt, a luminol analogue, is a widely used chemiluminescent (CL) probe for active oxygen and active nitrogen. L 012 sodium salt is widely used to detect the superoxides (O2•−) derived from NADPH oxidase (Nox) to find Nox inhibitors.

Others Reactive Oxygen Species ROS

In Stock

Size

QTY

Mito-TEMPO

T194281334850-99-5

Mito-TEMPO, a mitochondria-targeted superoxide dismutase mimetic, scavenges superoxide and alkyl radicals, preventing mitochondrial oxidation, necrosis, and apoptosis.

Mitochondrial Metabolism Reactive Oxygen Species ROS

In Stock

Size

QTY

Cited

p-Cresyl sulfate

T219773233-58-7

p-Cresyl Sulfate is the major uremic toxin present in the blood of patients with chronic kidney disease and is derived from the metabolites of tyrosine and phenylalanine in the liver.

Endogenous Metabolite JNK Others p38 MAPK ROS

In Stock

Size

QTY

SFI003

T720682361332-90-1In house

SFI003 is a novel SRSF3 inhibitor that exerts anticancer activity against colorectal cancer by modulating the SRSF3 / DHCR24 / ROS axis and driving apoptosis in CRC cells through the SRSF3 / DHCR24 / reactive oxygen species (ROS) axis.

Apoptosis Reactive Oxygen Species ROS

In Stock

Size

QTY

Entrectinib

RXDX-101, NMS-E628

T36781108743-60-7

Entrectinib (RXDX-101) is a Trk, ROS1, and ALK inhibitor that inhibits TrkA, TrkB, TrkC, ROS1, and ALK (IC50=1/3/5/12/7 nM) with oral activity and blood-brain-barrier penetration. Entrectinib exhibits both antitumor and CNS activity.

ALK Autophagy ROS ROS Kinase Trk receptor

In Stock

Size

QTY

Cited

Zinc Protoporphyrin

ZnPP, Zn(II)-protoporphyrin IX, Zinc Protoporphyrin-9

T1339615442-64-5

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active, competitive inhibitor of heme oxygenase-1 (HO-1) that markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 and exhibits anti-cancer activity.

Apoptosis Endogenous Metabolite Reactive Oxygen Species ROS

In Stock

Size

QTY

Cited

H2DCFDA

DCFH-DA, 2',7'-Dichlorodihydrofluorescein diacetate

T154584091-99-0

H2DCFDA (DCFH-DA) belongs to the class of green fluorescent dyes and is a probe for the detection of intracellular reactive oxygen species (ROS) (Ex/Em=488/525 nm) with cell membrane permeability.

Reactive Oxygen Species ROS

In Stock

Size

QTY

Cited

L-Ascorbic acid

Vitamin C, L-Ascorbate, L(+)-Ascorbic acid, Ascorbic acid

T092850-81-7

L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-Ascorbic acid is used in the treatment of scurvy.

Apoptosis Calcium Channel Endogenous Metabolite Reactive Oxygen Species ROS

In Stock

Size

QTY

Cited

Moracin C

TN194969120-06-5In house

Moracin C, a natural compound found in Morus mesozygia, Morus alba var. multicaulis, is an anti-inflammatory agent. moracin C inhibits nitric oxide (NO) release and LPS-activated reactive oxygen species (ROS) in cells.

COX NO Synthase Reactive Oxygen Species ROS

$198

In Stock

Size

QTY

DMPO

5,5-Dimethyl-1-pyrroline N-oxide

T227393317-61-1

DMPO (5,5-Dimethyl-1-pyrroline N-oxide) is a kind of water-soluble nitric oxide spin trap, which allows the measurement of oxygen-centered free radicals in biological systems at room temperature using electron spin resonance. It has a high reaction rate constant for superoxide and hydroxyl radicals and distinguishes simultaneously among a variety of important biologically generated free radicals.

NO Synthase Others Reactive Oxygen Species ROS

In Stock

Size

QTY

Cited

Trolox

T171053188-07-1

Trolox is a vitamin E analogue, used in reducing oxidative stress or damage.

Antioxidant Apoptosis Ferroptosis Reactive Oxygen Species ROS

In Stock

Size

QTY

Cited

Medicarpin

TN191832383-76-9

N-Methylnicotinamide is one of the endogenous metabolites that ameliorates endothelial dysfunction.

Apoptosis Bcl-2 Family JNK ROS

$117

In Stock

Size

QTY

Cited

Linsidomine hydrochloride

SIN-1 chloride

T2335616142-27-1

Linsidomine hydrochloride (SIN-1 chloride) is considered as a metabolite of moxidomine, with vasodilation, inhibition of platelet aggregation, and antiangina activity. In myocardial ischemia-reperfusion models, Linsidomine hydrochloride to reduce myocardial necrosis and reperfusion induced endothelial dysfunction is associated with the cavernosal mechanism of action involved in nitric oxide release.

Annexin A Apoptosis Autophagy Drug Metabolite NF-κB ROS

In Stock

Size

QTY

DPPH

2,2-Diphenyl-1-picrylhydrazyl

T110931898-66-4

DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a cell-permeable, stable free radical commonly used to evaluate the free radical scavenging ability, hydrogen donation capacity of compounds, and to measure the antioxidant activity of tissue extracts.

Others ROS

In Stock

Size

QTY

Cited

Echinacoside

T171682854-37-3

Echinacoside is a natural polyphenolic compound with various kinds of pharmacological activities, such as anti-inflammatory, antioxidative, hepatoprotective, neuroprotective, nitric oxide radical-scavenging and vasodilative ones.

Reactive Oxygen Species ROS Wnt/beta-catenin

In Stock

Size

QTY

Cited

Succinyl phosphonate trisodium salt

T13019864167-45-3

Succinyl phosphonate trisodium salt is an inhibitor of α-ketoglutarate dehydrogenase (KGDHC).

Dehydrogenase Endogenous Metabolite Reactive Oxygen Species ROS

$139

In Stock

Size

QTY

N-acetylcysteine amide

T551838520-57-9

N-Acetylcysteine amide is a thiol antioxidant and a neuroprotective agent with cell permeability and blood-brain barrier permeability. N-Acetylcysteine amide reduces ROS production.

Reactive Oxygen Species ROS

In Stock

Size

QTY

Cited

Go to page 1

Page of 9