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IL-6R alpha/CD126 Protein, Human, Recombinant (His & Avi)
(Synonyms: IL-6R-α, IL6RQ, IL-6R-alpha, IL-6RA, IL-6R subunit α, IL-6R subunit alpha, IL-6R 1, IL6R, IL-6 R α/CD126, gp80, CD126) Copy Product InfoSynonyms: IL-6R-α, IL6RQ, IL-6R-alpha, IL-6RA, IL-6R subunit α, IL-6R subunit alpha, IL-6R 1, IL6R, IL-6 R α/CD126, gp80, CD126
Catalog No. TMPK-00289 Copy Product Info
The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6R alpha) and a signal-transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. Both components of the receptor complex, IL-6R alpha and gp130 have been cloned, sequenced, and expressed.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $58 | - | In Stock | |
| 10 µg | $92 | - | In Stock | |
| 20 µg | $148 | - | In Stock | |
| 50 µg | $289 | 7-10 days | 7-10 days | |
| 100 µg | $487 | - | In Stock | |
| 200 µg | $883 | 7-10 days | 7-10 days | |
| 500 µg | $1,950 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | 1. Immobilized Human IL-6, No Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Human IL-6 R alpha, His Tag with the EC50 of 0.15μg/ml determined by ELISA.
2. Human IL-6 R alpha, His Tag captured on CM5 Chip via anti-his antibody can bind Human IL-6, No Tag with an affinity constant of 0.22 nM as determined in SPR assay. |
| Description | The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6R alpha) and a signal-transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. Both components of the receptor complex, IL-6R alpha and gp130 have been cloned, sequenced, and expressed. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His-Avi |
| Accession Number | P08887-1 |
| Construction | Leu20-Pro365 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | IL-6R-α, IL6RQ, IL-6R-alpha, IL-6RA, IL-6R subunit α, IL-6R subunit alpha, IL-6R 1, IL6R, IL-6 R α/CD126, gp80, CD126 |
| Research Background | The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6R alpha) and a signal-transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. Both components of the receptor complex, IL-6R alpha and gp130 have been cloned, sequenced, and expressed. |
| Molecular Weight | 41.4 kDa (predicted). Due to glycosylation, the protein migrates to 65-78 kDa based on Tris-Bis PAGE result. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: IL-6R alpha/CD126 Protein, Human, Recombinant (His & Avi) chemical structure | IL-6R alpha/CD126 Protein, Human, Recombinant (His & Avi) molecular weight
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