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DSM265

Name: DSM265
Brand: TargetMol
SKU: T15173
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15173Cas No. 1282041-94-4

Alias PfSPZ

DSM265 (PfSPZ) is a dihydroorotic acid dehydrogenase inhibitor with antimalarial activity (IC50: 8.9 nM).DSM265 inhibits the growth of Pf3D7 parasites and can be used for the treatment and prophylaxis of malaria infections.

DSM265

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Purity: 99.79%

Catalog No. T15173Alias PfSPZCas No. 1282041-94-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	-	In Stock
5 mg	$64	-	In Stock
10 mg	$89	-	In Stock
1 mL x 10 mM (in DMSO)	$68	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.79%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	DSM265 (PfSPZ) is a dihydroorotic acid dehydrogenase inhibitor with antimalarial activity (IC50: 8.9 nM).DSM265 inhibits the growth of Pf3D7 parasites and can be used for the treatment and prophylaxis of malaria infections.
Targets&IC50	P. falciparum (3D7 parasites):4.3 nM (EC50), PfDHODH:8.9 nM
In vivo	In NOD-scid IL-2Rγnull (NSG) mice (23-36 g), DSM265 (0.5 - 75 mg/kg; oral administration; twice daily; for 4 days) exhibited potent antimalarial activity[2].
Synonyms	PfSPZ

Chemical Properties

Molecular Weight	415.33
Formula	C₁₄H₁₂F₇N₅S
Cas No.	1282041-94-4
Smiles	Cc1cc(Nc2ccc(cc2)S(F)(F)(F)(F)F)n2nc(nc2n1)C(C)(F)F
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble.)

Ethanol: 5 mg/mL (12.04 mM), Sonication is recommended.

DMSO: 30 mg/mL (72.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4077 mL	12.0386 mL	24.0772 mL	120.3862 mL
5 mM	0.4815 mL	2.4077 mL	4.8154 mL	24.0772 mL
10 mM	0.2408 mL	1.2039 mL	2.4077 mL	12.0386 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1204 mL	0.6019 mL	1.2039 mL	6.0193 mL
50 mM	0.0482 mL	0.2408 mL	0.4815 mL	2.4077 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc