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Anti-Arginase 1/ARG1 Antibody (5G793)
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Catalog No. TMAH-00080
Alias arginase 1, ARG1
Anti-Arginase 1/ARG1 Antibody (5G793) is an antibody targeting Arginase 1/ARG1. Anti-Arginase 1/ARG1 Antibody (5G793) can be used in ELISA, IHC.
Anti-Arginase 1/ARG1 Antibody (5G793)
Anti-Arginase 1/ARG1 Antibody (5G793)
😃Good
Catalog No. TMAH-00080Alias arginase 1, ARG1
Anti-Arginase 1/ARG1 Antibody (5G793) is an antibody targeting Arginase 1/ARG1. Anti-Arginase 1/ARG1 Antibody (5G793) can be used in ELISA, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, IHC Reactivity: Human |
| Alias | arginase 1, ARG1 |
| Ig Type | Rabbit IgG |
| Clone | 5G793 |
| Reactivity | Human |
| Verified Activity | IHC image of TMAH-00080 diluted at 1:50 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.71% DAB. |
| Application | ELISA, IHC |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Cytoplasmic granule. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion. In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival. In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human ARG1 |
| Antigen Species | Human |
| Gene ID | 383 |
| Uniprot ID | |
| Biology Area | Metabolism, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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