Shopping Cart
Remove All
Your shopping cart is currently empty
AZ PFKFB3 26
Copy Product Info
😃Good
Catalog No. T14365Cas No. 1704740-52-2
AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.
AZ PFKFB3 26
Copy Product Info😃Good
Purity: 99.85%
Catalog No. T14365Cas No. 1704740-52-2
AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $30 | In Stock | In Stock | |
| 5 mg | $43 | In Stock | In Stock | |
| 10 mg | $76 | In Stock | In Stock | |
| 25 mg | $173 | In Stock | In Stock | |
| 50 mg | $298 | In Stock | In Stock | |
| 100 mg | $415 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $54 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.85%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
AZ PFKFB3 26 AI Summary
AZ PFKFB3 26 is a bioactive compound exhibiting potent inhibitory activity against recombinant human PFKFB1, PFKFB2, and PFKFB3 enzymes, with varying IC50 values. It has moderate lipophilicity, reflected by a logD value of 3.5, and good aqueous solubility. The compound shows a low fraction unbound in rat plasma and a moderate fraction unbound in human plasma. In cellular assays, AZ PFKFB3 26 inhibits PFKFB3, reducing fructose-1,6-bisphosphate formation and lactate secretion. It demonstrates good permeability in human Caco-2 cells and possesses an efflux ratio. The compound has favorable oral bioavailability in both CD1 mouse and Wistar rat models, with good absorption and a relatively low volume of distribution in mice compared to rats. It undergoes species-dependent clearance rates. In vivo, the compound exhibits a reasonable half-life in mice and rats and achieves high exposure levels in nude mice based on AUC and Cmax values. Additionally, AZ PFKFB3 26 shows selectivity towards PFKFB2 over PFKFB3 based on IC50 values..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively. |
| Targets&IC50 | PFKFB1:2.06 μM, PFKFB3:23 nM, PFKFB2:0.384 μM |
| Molecular Weight | 402.49 |
| Formula | C24H26N4O2 |
| Cas No. | 1704740-52-2 |
| Smiles | CC(C)Cn1cc(C#N)c2cc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc12 |
| Relative Density. | 1.24 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.5 mg/mL (11.18 mM), when pH is adjusted to 3 with HCl. Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
| |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy AZ PFKFB3 26 | purchase AZ PFKFB3 26 | AZ PFKFB3 26 cost | order AZ PFKFB3 26 | AZ PFKFB3 26 chemical structure | AZ PFKFB3 26 formula | AZ PFKFB3 26 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.