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Ondansetron hydrochloride

Name: Ondansetron hydrochloride
Brand: TargetMol
SKU: T6616
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6616Cas No. 99614-01-4

Alias Zofran, SN 307, Ondansetron HCl, NSC 665799, GR 38032 HCl, Emeset

Ondansetron hydrochloride (Zofran) is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.

Ondansetron hydrochloride

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Purity: 99.78%

Catalog No. T6616Alias Zofran, SN 307, Ondansetron HCl, NSC 665799, GR 38032 HCl, EmesetCas No. 99614-01-4

Ondansetron hydrochloride (Zofran) is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$37	In Stock	In Stock
50 mg	$53	In Stock	In Stock
100 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.78%

Appearance:Solid

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Ondansetron hydrochloride AI Summary

Ondansetron hydrochloride shows multifunctional bioactivity, primarily exhibiting inhibition of the Choline Transporter (CHT) with IC50 values of 1674.11 nM and 1353.46 nM in different assays. It also functions as a GLP-1 Receptor Agonist with a potency of 8912.5 nM. Additionally, it inhibits cell viability in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1) at a 0.002 MOI after 72 hours, demonstrating higher activity compared to the arbidol control with an inhibition index of 1.665. The compound's effects on cell viability vary depending on the cell type; it promotes cell viability in HEK293T (growth rates 0.6 to 0.87) and human fibroblasts (growth rate 0.9), while showing a broader range of impacts in U2OS cells (growth rates -0.28 to 0.96)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ondansetron hydrochloride (Zofran) is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.
Targets&IC50	5-HT:3.4 microM(EC50), 5-HT3:103 pM
Synonyms	Zofran, SN 307, Ondansetron HCl, NSC 665799, GR 38032 HCl, Emeset

Chemical Properties

Molecular Weight	329.82
Formula	C₁₈H₁₉N₃O·HCl
Cas No.	99614-01-4
Smiles	Cl.CN1C2=CC=CC=C2C2=C1CCC(CN1C=CN=C1C)C2=O
Relative Density.	1.27g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 16.5 mg/mL (50.03 mM), Sonication is recommended.

DMSO: 60 mg/mL (181.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (15.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0320 mL	15.1598 mL	30.3196 mL	151.5978 mL
5 mM	0.6064 mL	3.0320 mL	6.0639 mL	30.3196 mL
10 mM	0.3032 mL	1.5160 mL	3.0320 mL	15.1598 mL
20 mM	0.1516 mL	0.7580 mL	1.5160 mL	7.5799 mL
50 mM	0.0606 mL	0.3032 mL	0.6064 mL	3.0320 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0303 mL	0.1516 mL	0.3032 mL	1.5160 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc