Shopping Cart
Remove All
Your shopping cart is currently empty
APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His)
(Synonyms: Tumor necrosis factor ligand superfamily member 13, TRDL-1, TNFSF13, TNF-related death ligand 1, TNF- and APOL-related leukocyte expressed ligand 2, TALL-2, CD256, APRIL, A proliferation-inducing ligand) Copy Product InfoSynonyms: Tumor necrosis factor ligand superfamily member 13, TRDL-1, TNFSF13, TNF-related death ligand 1, TNF- and APOL-related leukocyte expressed ligand 2, TALL-2, CD256, APRIL, A proliferation-inducing ligand
Catalog No. TMPJ-00137 Copy Product Info
Purity: 99%
APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. Secreted human APRIL, which consists almost entirely of a single TNF homology domain, shares 85% amino acid sequence identity with mouse and rat APRIL. Both APRIL and its close relative BAFF bind and signal through the TNF superfamily receptors TACI and BCMA, while BAFF additionally functions through BAFF R. APRIL binds to heparan sulfate proteoglycans (HSPGs) independently of its binding to TACI and BCMA. APRIL can form bioactive heterotrimers with BAFF, and these circulate in the serum of patients with rheumatic immune disorders. APRIL enhances the proliferation and survival of plasma cells and also promotes T cell-dependent humoral responses. APRIL levels are elevated in the serum during coronary artery disease, and it is also elevated in many cancers primarily due to expression by tumor-infiltratin neutrophils.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $178 | 7-10 days | 7-10 days | |
| 10 μg | $283 | - | In Stock | |
| 20 μg | $538 | 7-10 days | 7-10 days | |
| 50 μg | $793 | 7-10 days | 7-10 days | |
| 100 μg | $1,269 | 7-10 days | 7-10 days | |
| 200 μg | $2,030 | 7-10 days | 7-10 days | |
| 500 μg | $3,553 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Cart
Add to Quotation
For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
Select Batch
Purity:99%
Appearance:Lyophilized powder
Color:White
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. Secreted human APRIL, which consists almost entirely of a single TNF homology domain, shares 85% amino acid sequence identity with mouse and rat APRIL. Both APRIL and its close relative BAFF bind and signal through the TNF superfamily receptors TACI and BCMA, while BAFF additionally functions through BAFF R. APRIL binds to heparan sulfate proteoglycans (HSPGs) independently of its binding to TACI and BCMA. APRIL can form bioactive heterotrimers with BAFF, and these circulate in the serum of patients with rheumatic immune disorders. APRIL enhances the proliferation and survival of plasma cells and also promotes T cell-dependent humoral responses. APRIL levels are elevated in the serum during coronary artery disease, and it is also elevated in many cancers primarily due to expression by tumor-infiltratin neutrophils. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | N-Flag-His |
| Accession Number | O75888 |
| Amino Acid | Lys112-Leu250 |
| Construction | Lys112-Leu250 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) https://cdn.targetmol.com/group3/M00/13/66/CgoaEWZG0y-ERGyqAAAAAMLPcGE103.png |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 1M NaCl, pH8.3. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | Tumor necrosis factor ligand superfamily member 13, TRDL-1, TNFSF13, TNF-related death ligand 1, TNF- and APOL-related leukocyte expressed ligand 2, TALL-2, CD256, APRIL, A proliferation-inducing ligand |
| Research Background |
| Molecular Weight | 60 KDa (reducing condition) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
Calculator
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His) chemical structure | APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His) molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.