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Ginsenoside Rg1

Name: Ginsenoside Rg1
Brand: TargetMol
SKU: T2777
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2777Cas No. 22427-39-0

Alias Sanchinoside Rg1, Sanchinoside C1, Panaxoside Rg1, Panaxoside A, Ginsenoside A2

Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and increase hippocampal synaptophysin level in mice, plus demonstrates estrogen-like activity.

Ginsenoside Rg1

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Purity: 99.92%

Catalog No. T2777Alias Sanchinoside Rg1, Sanchinoside C1, Panaxoside Rg1, Panaxoside A, Ginsenoside A2Cas No. 22427-39-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$37	In Stock	In Stock
25 mg	$52	In Stock	In Stock
50 mg	$60	In Stock	In Stock
100 mg	$70	In Stock	In Stock
500 mg	$163	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.92%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Ginsenoside Rg1 AI Summary

Ginsenoside Rg1 exhibits significant hepatoprotective activity against D-galactosamine/TNFalpha and D-galactosamine/LPS-induced liver injuries. In mouse hepatocytes, it improves cell survival rates at concentrations of 50 µM, 100 µM, and 200 µM, with notable efficacy in inhibiting cell death, evidenced by an IC50 of 111,000 nM. In ddY mice, a 100 mg/kg dosage administered intraperitoneally before the challenge reduces serum alanine transaminase (30.0%) and aspartate transaminase levels (12.0%). Additionally, Ginsenoside Rg1 inhibits superoxide anion generation (14.1% inhibition at 30 µM) and neutrophil degranulation (19.0% inhibition of elastase release at 30 µM) in fMLP/CB-stimulated human neutrophils. It promotes neurite outgrowth in SK-N-SH cells by 107.3% at 100 µM over 5 days and demonstrates a GI50 of 100,000 nM against various human tumor cell lines, indicating its potential in cancer growth inhibition. Lastly, it shows cytoprotective activity by reducing BaP-induced DNA strand breakage by 20.97% at 10 µM in neonatal HDF cells, though it also exhibits cytotoxic effects, reducing cell viability by 98.0% at the same concentration and exposure time..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and increase hippocampal synaptophysin level in mice, plus demonstrates estrogen-like activity.
Synonyms	Sanchinoside Rg1, Sanchinoside C1, Panaxoside Rg1, Panaxoside A, Ginsenoside A2

Chemical Properties

Molecular Weight	801.01
Formula	C₄₂H₇₂O₁₄
Cas No.	22427-39-0
Smiles	[H][C@@]12[C@H](CC[C@@]1(C)[C@]1(C)C[C@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)[C@@]1([H])C[C@H]2O)[C@](C)(CCC=C(C)C)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Relative Density.	1.33 g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (62.42 mM), Sonication is recommended.

H2O: 20 mg/mL (24.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2484 mL	6.2421 mL	12.4842 mL	62.4212 mL
5 mM	0.2497 mL	1.2484 mL	2.4968 mL	12.4842 mL
10 mM	0.1248 mL	0.6242 mL	1.2484 mL	6.2421 mL
20 mM	0.0624 mL	0.3121 mL	0.6242 mL	3.1211 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0250 mL	0.1248 mL	0.2497 mL	1.2484 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc