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Anti-E-Cadherin/Cadherin-1 Antibody (5K913)
🥰Excellent
Catalog No. TMAY-03799
Anti-E-Cadherin/Cadherin-1 Antibody (5K913) is a Mouse antibody targeting E-Cadherin/Cadherin-1. Anti-E-Cadherin/Cadherin-1 Antibody (5K913) can be used in ELISA.
Anti-E-Cadherin/Cadherin-1 Antibody (5K913)
Anti-E-Cadherin/Cadherin-1 Antibody (5K913)
🥰Excellent
Catalog No. TMAY-03799
Anti-E-Cadherin/Cadherin-1 Antibody (5K913) is a Mouse antibody targeting E-Cadherin/Cadherin-1. Anti-E-Cadherin/Cadherin-1 Antibody (5K913) can be used in ELISA.
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Product Introduction
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Chemical Properties
| Description | Anti-E-Cadherin/Cadherin-1 Antibody (5K913) is a Mouse antibody targeting E-Cadherin/Cadherin-1. Anti-E-Cadherin/Cadherin-1 Antibody (5K913) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 5K913 |
| Reactivity | Rat |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat E-Cadherin/CDH1/E-cad/CD324 (rR E-Cadherin/CDH1/E-cad/CD324; TMPY-04041; Q9R0T4; Met1-Ala713). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Rat E-Cadherin/CDH1/E-cad/CD324 Protein (TMPY-04041) |
| Antigen Species | Rat |
| Biology Area | Hemangioblast Markers, Tumor Suppressors |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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