This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
S-Adenosyl-L-methionine (SAMe) 1,4-butanedisulfonate functions as an orally active methyl group donor and serves as a dietary supplement known for its significant antidepressant properties. Additionally, it plays anti-proliferative, pro-apoptotic, and anti-metastatic roles in cancer. SAMe 1,4-butanedisulfonate holds promise in research pertaining to cancer, liver disease, and osteoarthritis [1] [2] [3].
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S-Adenosyl-L-methionine (1,4-butanedisulfonate), CAS 200393-05-1
S-Adenosyl-L-methionine (SAMe) 1,4-butanedisulfonate functions as an orally active methyl group donor and serves as a dietary supplement known for its significant antidepressant properties. Additionally, it plays anti-proliferative, pro-apoptotic, and anti-metastatic roles in cancer. SAMe 1,4-butanedisulfonate holds promise in research pertaining to cancer, liver disease, and osteoarthritis [1] [2] [3].
In vitro
S-Adenosyl-L-methionine at a concentration of 300 µM for 24 or 48 hours in its 1,4-butanedisulfonate form induces apoptosis and facilitates cell cycle arrest in Cal-33 and JHU-SCC-011 cells [4]. Similarly, S-Adenosyl-L-methionine (300 µM, 24 h) 1,4-butanedisulfonate reduces migration in both Cal-33 and JHU-SCC-011 cell lines [4]. Additionally, when administered at doses ranging from 5 to 40 μg/mL for 48 hours, 1,4-butanedisulfonate-derivative S-Adenosyl-L-methionine modulates the expression of DNMTs, thereby preserving the anticancer efficacy of 5-FU [5].
In vivo
S-Adenosyl-L-methionine (30 mg/kg, orally administered for 3 consecutive days) 1,4-butanedisulfonate has been shown to prevent ASD-like behaviors induced by early postnatal valproate exposure in young mice [6]. Additionally, at doses of 50 and 100 mg/kg administered orally, 1,4-butanedisulfonate exhibits antiepileptic, memory-enhancing, and antioxidant properties in a pentylenetetrazole-induced rat model of epilepsy [7].
Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.